Nutritional hepatic iron overload is not prevented by parenteral hepcidin

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F12%3A00009832" target="_blank" >RIV/00023736:_____/12:00009832 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1017/S0007114512000116" target="_blank" >http://dx.doi.org/10.1017/S0007114512000116</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1017/S0007114512000116" target="_blank" >10.1017/S0007114512000116</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nutritional hepatic iron overload is not prevented by parenteral hepcidin

Popis výsledku v původním jazyce

The peptide hormone hepcidin functions as a negative regulator of intestinal Fe absorption and Fe recycling. Since its discovery as a systemic negative regulator of Fe metabolism, hepcidin has attracted enormous interest as a potential drug for the treatment and/or prevention of several forms of Fe overload. We therefore tested whether multiple doses of intraperitoneally administered synthetic renatured hepcidin can prevent hepatic Fe loading in mice concurrently fed an Fe-rich diet, and whether the same treatment affects hepatic Fe stores in mice fed a normal diet. Cohorts of male mice were fed either a normal defined diet (180parts per million Fe) or an Fe-rich diet (the same diet supplemented with 2% carbonyl iron for 2 weeks). Concurrently, half ofthe animals in each diet group received 100 ?g of renatured hepcidin intraperitoneally every 12h, for the same 2-week period. The second half of the animals received PBS only. The renatured synthetic hepcidin demonstrated biological acti

Název v anglickém jazyce

Nutritional hepatic iron overload is not prevented by parenteral hepcidin

Popis výsledku anglicky

The peptide hormone hepcidin functions as a negative regulator of intestinal Fe absorption and Fe recycling. Since its discovery as a systemic negative regulator of Fe metabolism, hepcidin has attracted enormous interest as a potential drug for the treatment and/or prevention of several forms of Fe overload. We therefore tested whether multiple doses of intraperitoneally administered synthetic renatured hepcidin can prevent hepatic Fe loading in mice concurrently fed an Fe-rich diet, and whether the same treatment affects hepatic Fe stores in mice fed a normal diet. Cohorts of male mice were fed either a normal defined diet (180parts per million Fe) or an Fe-rich diet (the same diet supplemented with 2% carbonyl iron for 2 weeks). Concurrently, half ofthe animals in each diet group received 100 ?g of renatured hepcidin intraperitoneally every 12h, for the same 2-week period. The second half of the animals received PBS only. The renatured synthetic hepcidin demonstrated biological acti

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

British journal of nutrition

ISSN

0007-1145

e-ISSN

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Svazek periodika

108

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

3

Strana od-do

1723-1725

Kód UT WoS článku

000311399400001

EID výsledku v databázi Scopus

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