The heterochromatin condensation state in peripheral "gene poor" and central "gene rich" nuclear regions of less differentiated and mature human leukemic cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F14%3A00011249" target="_blank" >RIV/00023736:_____/14:00011249 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.4172/2329-6917.1000151" target="_blank" >http://dx.doi.org/10.4172/2329-6917.1000151</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4172/2329-6917.1000151" target="_blank" >10.4172/2329-6917.1000151</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The heterochromatin condensation state in peripheral "gene poor" and central "gene rich" nuclear regions of less differentiated and mature human leukemic cells

Popis výsledku v původním jazyce

As it is generally known, the heterochromatin is an useful marker of the cell differentiation and maturity including their pathology. The goal of the study was to provide more information on the heterochromatin ? DNA ? condensation state in nuclear genepoor periphery and central gene rich nuclear regions of single proliferating progenitors and mature of human leukemic cells in situ. The results indicated that in central nuclear regions the heterochromatin condensation state is larger than at the nuclear periphery. During the cell differentiation and maturation the heterochromatin condensation state in the nuclear periphery increased and reached the same density as in the central nuclear regions. Since the heterochromatin possesses dormant genes it seems to be likely that it represents a further possibility of the genome conservation and stability in both regions of the cell nucleus.

Název v anglickém jazyce

The heterochromatin condensation state in peripheral "gene poor" and central "gene rich" nuclear regions of less differentiated and mature human leukemic cells

Popis výsledku anglicky

As it is generally known, the heterochromatin is an useful marker of the cell differentiation and maturity including their pathology. The goal of the study was to provide more information on the heterochromatin ? DNA ? condensation state in nuclear genepoor periphery and central gene rich nuclear regions of single proliferating progenitors and mature of human leukemic cells in situ. The results indicated that in central nuclear regions the heterochromatin condensation state is larger than at the nuclear periphery. During the cell differentiation and maturation the heterochromatin condensation state in the nuclear periphery increased and reached the same density as in the central nuclear regions. Since the heterochromatin possesses dormant genes it seems to be likely that it represents a further possibility of the genome conservation and stability in both regions of the cell nucleus.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of leukemia [online]

ISSN

2329-6917

e-ISSN

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Svazek periodika

2

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

"art. no. 1000151"

Kód UT WoS článku

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EID výsledku v databázi Scopus

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