Distinct patterns of intratumoral immune cell infiltrates in patients with HPV-associated compared to non-virally induced head and neck squamous cell carcinoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F15%3A00011196" target="_blank" >RIV/00023736:_____/15:00011196 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/15:10294608 RIV/00216208:11110/15:10294608 RIV/00216208:11130/15:10294608 RIV/00064203:_____/15:10294608

Výsledek na webu

<a href="http://www.scopus.com/inward/record.url?eid=2-s2.0-84938717670&partnerID=40&md5=8be21d8bdeb67e8782e9b3348524a02a" target="_blank" >http://www.scopus.com/inward/record.url?eid=2-s2.0-84938717670&partnerID=40&md5=8be21d8bdeb67e8782e9b3348524a02a</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4161/21624011.2014.965570" target="_blank" >10.4161/21624011.2014.965570</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Distinct patterns of intratumoral immune cell infiltrates in patients with HPV-associated compared to non-virally induced head and neck squamous cell carcinoma

Popis výsledku v původním jazyce

In this study, we analyzed a detailed immune profile of tumor samples from HNSCC patients with respect to their HPV status. We analyzed the characteristics of immune cell infiltrates, including the frequency and distribution of antigen-presenting cells and naïve, regulatory and effector T cells and the cytokine and chemokine levels in tumor tissue. The presence of a high level of intratumoral immune cell infiltrates might play a crucial role in the significantly better response of HPV-positive patients to standard therapy and their favorable clinical outcome. Characterization of the HNSCC immune profile might be a valuable prognostic tool in addition to HPV status and might help identify novel targets for therapeutic strategies, including cancer immunotherapy

Název v anglickém jazyce

Distinct patterns of intratumoral immune cell infiltrates in patients with HPV-associated compared to non-virally induced head and neck squamous cell carcinoma

Popis výsledku anglicky

In this study, we analyzed a detailed immune profile of tumor samples from HNSCC patients with respect to their HPV status. We analyzed the characteristics of immune cell infiltrates, including the frequency and distribution of antigen-presenting cells and naïve, regulatory and effector T cells and the cytokine and chemokine levels in tumor tissue. The presence of a high level of intratumoral immune cell infiltrates might play a crucial role in the significantly better response of HPV-positive patients to standard therapy and their favorable clinical outcome. Characterization of the HNSCC immune profile might be a valuable prognostic tool in addition to HPV status and might help identify novel targets for therapeutic strategies, including cancer immunotherapy

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

OncoImmunology

ISSN

2162-4011

e-ISSN

—

Svazek periodika

4

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

"art. no. e965570"

Kód UT WoS článku

000349387800004

EID výsledku v databázi Scopus

2-s2.0-84938717670