The detection of human polyomaviruses MCPyV, HPyV6, and HPyV7 in malignant and non-malignant tonsillar tissues

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F16%3A00011377" target="_blank" >RIV/00023736:_____/16:00011377 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/jmv.24385" target="_blank" >http://dx.doi.org/10.1002/jmv.24385</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jmv.24385" target="_blank" >10.1002/jmv.24385</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The detection of human polyomaviruses MCPyV, HPyV6, and HPyV7 in malignant and non-malignant tonsillar tissues

Popis výsledku v původním jazyce

Merkel cell polyomavirus (MCPyV) is associated with Merkel cell carcinoma (MCC), a rare skin malignancy. Human polyomavirus 6 and 7 (HPyV6 and HPyV7) were identified on a skin but have not been associated with any pathology. The serology data suggests that infection with polyomaviruses occurs in childhood and they are widespread in population. However, the site of persistent infection has not been identified. The prevalence of MCPyV DNA in non-malignant tonsils increased with age (p < 0.05). While the prevalence of MCPyV DNA was significantly higher in the tumors than non-malignant tissues (35.7% vs. 10.2%) (p < 0.001), the prevalence of HPyV6 DNA (5.4% vs. 4.6%) and HPyV7 DNA (1.8% vs. 0.9%) were comparable. In all MCPyV DNA positive FF tissues early transcripts were detected. MCPyV, HPyV6 and HPyV7 DNAs were found in tonsils, suggesting that the tonsils may be a site of viral latency. The viral load was low indicating that only a fraction of cells are infected.

Název v anglickém jazyce

The detection of human polyomaviruses MCPyV, HPyV6, and HPyV7 in malignant and non-malignant tonsillar tissues

Popis výsledku anglicky

Merkel cell polyomavirus (MCPyV) is associated with Merkel cell carcinoma (MCC), a rare skin malignancy. Human polyomavirus 6 and 7 (HPyV6 and HPyV7) were identified on a skin but have not been associated with any pathology. The serology data suggests that infection with polyomaviruses occurs in childhood and they are widespread in population. However, the site of persistent infection has not been identified. The prevalence of MCPyV DNA in non-malignant tonsils increased with age (p < 0.05). While the prevalence of MCPyV DNA was significantly higher in the tumors than non-malignant tissues (35.7% vs. 10.2%) (p < 0.001), the prevalence of HPyV6 DNA (5.4% vs. 4.6%) and HPyV7 DNA (1.8% vs. 0.9%) were comparable. In all MCPyV DNA positive FF tissues early transcripts were detected. MCPyV, HPyV6 and HPyV7 DNAs were found in tonsils, suggesting that the tonsils may be a site of viral latency. The viral load was low indicating that only a fraction of cells are infected.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT13867" target="_blank" >NT13867: Zjištění závažnosti infekce nově objevených DNA virů u zdravých a imunokompromitovaných pacientů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of medical virology

ISSN

0146-6615

e-ISSN

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Svazek periodika

88

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

695-702

Kód UT WoS článku

000369184300017

EID výsledku v databázi Scopus

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