Posttranslational modifications of red blood cell ghost proteins as ´signatures´ for distinguishing between low- and high-risk myelodysplastic syndrome patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F17%3A00011625" target="_blank" >RIV/00023736:_____/17:00011625 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.4274/tjh.2016.0251" target="_blank" >http://dx.doi.org/10.4274/tjh.2016.0251</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4274/tjh.2016.0251" target="_blank" >10.4274/tjh.2016.0251</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Posttranslational modifications of red blood cell ghost proteins as ´signatures´ for distinguishing between low- and high-risk myelodysplastic syndrome patients

Popis výsledku v původním jazyce

Myelodysplastic syndrome (MDS) comprises a heterogenic group of oncohematological diseases that affect hematopoiesis. Although the precise cause of MDS is unknown, multiple factors are involved, one of the most widely implicated of which is oxidative stress. However, it is unclear whether oxidative stress is a cause of MDS or an effect of other pathological mechanisms. Red blood cells (RBC) are the first cells exposed to stress stimuli. They are highly vulnerable to free radical accumulation, which leads to the oxidative stress that induces damage in proteins and other biomacromolecules. In MDS, the RBC proteome can be affected by effects of the peripheral blood environment of and/or by abnormal processes possibly caused by oxidative stress during hematopoiesis in bone marrow. Therefore, we chose red cell membranes (ghosts) as a model biological material.

Název v anglickém jazyce

Posttranslational modifications of red blood cell ghost proteins as ´signatures´ for distinguishing between low- and high-risk myelodysplastic syndrome patients

Popis výsledku anglicky

Myelodysplastic syndrome (MDS) comprises a heterogenic group of oncohematological diseases that affect hematopoiesis. Although the precise cause of MDS is unknown, multiple factors are involved, one of the most widely implicated of which is oxidative stress. However, it is unclear whether oxidative stress is a cause of MDS or an effect of other pathological mechanisms. Red blood cells (RBC) are the first cells exposed to stress stimuli. They are highly vulnerable to free radical accumulation, which leads to the oxidative stress that induces damage in proteins and other biomacromolecules. In MDS, the RBC proteome can be affected by effects of the peripheral blood environment of and/or by abnormal processes possibly caused by oxidative stress during hematopoiesis in bone marrow. Therefore, we chose red cell membranes (ghosts) as a model biological material.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

<a href="/cs/project/GBP205%2F12%2FG118" target="_blank" >GBP205/12/G118: Nanobiofotonika pro medicínu budoucnosti</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Turkish Journal of Haematology

ISSN

1300-7777

e-ISSN

—

Svazek periodika

34

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

TR - Turecká republika

Počet stran výsledku

3

Strana od-do

111-113

Kód UT WoS článku

000398059500024

EID výsledku v databázi Scopus

2-s2.0-85014469972