Formation of the 3´-ends of eukaryotic messenger RNAs: polyadenylation and alternative polyadenylation
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F18%3A00011941" target="_blank" >RIV/00023736:_____/18:00011941 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Formation of the 3´-ends of eukaryotic messenger RNAs: polyadenylation and alternative polyadenylation
Popis výsledku v původním jazyce
Author reviews the currently available data on interactions of ribosomal components with canonical mRNAs and with hepatitis C virus (HCV)-like IRESes during translation and on conformational rearrangements in the ribosomes accompanying these interactions. This review considers data obtained by biochemical approaches, primarily by site-directed cross-linking with the application of mRNA and IRES analogues bearing reactive groups in definite locations, and models for translational complexes of higher eukaryotic ribosomes derived from cryo-electron microscopy. In closing author presents his findings that splicing is not only necessary for obtaining correct open reading frames, but also leads to deposition of the exon junction complex core. Essentially, all pre-mRNAs are cleaved and polyadenylated with exception of histone mRNAs.
Název v anglickém jazyce
Formation of the 3´-ends of eukaryotic messenger RNAs: polyadenylation and alternative polyadenylation
Popis výsledku anglicky
Author reviews the currently available data on interactions of ribosomal components with canonical mRNAs and with hepatitis C virus (HCV)-like IRESes during translation and on conformational rearrangements in the ribosomes accompanying these interactions. This review considers data obtained by biochemical approaches, primarily by site-directed cross-linking with the application of mRNA and IRES analogues bearing reactive groups in definite locations, and models for translational complexes of higher eukaryotic ribosomes derived from cryo-electron microscopy. In closing author presents his findings that splicing is not only necessary for obtaining correct open reading frames, but also leads to deposition of the exon junction complex core. Essentially, all pre-mRNAs are cleaved and polyadenylated with exception of histone mRNAs.
Klasifikace
Druh
C - Kapitola v odborné knize
CEP obor
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OECD FORD obor
30205 - Hematology
Návaznosti výsledku
Projekt
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Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název knihy nebo sborníku
mRNA: molecular biology, processing and function
ISBN
978-1-53613-168-0
Počet stran výsledku
25
Strana od-do
43-68
Počet stran knihy
152
Název nakladatele
Nova Science
Místo vydání
New York
Kód UT WoS kapitoly
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