Regulatory roles of sumoylation in messenger RNA processing and metabolism

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Regulatory roles of sumoylation in messenger RNA processing and metabolism

Popis výsledku v původním jazyce

Author discusses how the addition of the poly(A) tail of 30-100 adenosines to the 3´-end of mRNA has been shown to be important for the stability, nuclear export, export of mRNA to the cytoplasm and translation of a transcript. The molecular mechanism responsible for the definition of a poly(A) site includes several recognition, cleavage and polyadenylation factors that identify the poly(A) signal, usually AAUAAA hexamer and similar variants, located 10-35 nucleotides upstream of the cleavage site. The process known as SUMO (small ubiquitin-related modifier) conjugation to a lysine residue in the target protein or sumoylation is a rapid, reversible post-transcriptional modification is also examined. Similar to ubiquitin, SUMO isoforms are conjugated to their targets by a isopeptide bond between their C-terminal glycine and the ɛ-NH2 group of the target lysine residue.

Název v anglickém jazyce

Regulatory roles of sumoylation in messenger RNA processing and metabolism

Popis výsledku anglicky

Author discusses how the addition of the poly(A) tail of 30-100 adenosines to the 3´-end of mRNA has been shown to be important for the stability, nuclear export, export of mRNA to the cytoplasm and translation of a transcript. The molecular mechanism responsible for the definition of a poly(A) site includes several recognition, cleavage and polyadenylation factors that identify the poly(A) signal, usually AAUAAA hexamer and similar variants, located 10-35 nucleotides upstream of the cleavage site. The process known as SUMO (small ubiquitin-related modifier) conjugation to a lysine residue in the target protein or sumoylation is a rapid, reversible post-transcriptional modification is also examined. Similar to ubiquitin, SUMO isoforms are conjugated to their targets by a isopeptide bond between their C-terminal glycine and the ɛ-NH2 group of the target lysine residue.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

30205 - Hematology

Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

mRNA: molecular biology, processing and function

ISBN

978-1-53613-168-0

Počet stran výsledku

27

Strana od-do

69-96

Počet stran knihy

152

Název nakladatele

Nova Science

Místo vydání

New York

Kód UT WoS kapitoly

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