Regulatory roles of sumoylation in messenger RNA processing and metabolism
Popis výsledku
Identifikátory výsledku
Kód výsledku v IS VaVaI
Výsledek na webu
https://www.novapublishers.com/catalog/product_info.php?products_id=63968
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Regulatory roles of sumoylation in messenger RNA processing and metabolism
Popis výsledku v původním jazyce
Author discusses how the addition of the poly(A) tail of 30-100 adenosines to the 3´-end of mRNA has been shown to be important for the stability, nuclear export, export of mRNA to the cytoplasm and translation of a transcript. The molecular mechanism responsible for the definition of a poly(A) site includes several recognition, cleavage and polyadenylation factors that identify the poly(A) signal, usually AAUAAA hexamer and similar variants, located 10-35 nucleotides upstream of the cleavage site. The process known as SUMO (small ubiquitin-related modifier) conjugation to a lysine residue in the target protein or sumoylation is a rapid, reversible post-transcriptional modification is also examined. Similar to ubiquitin, SUMO isoforms are conjugated to their targets by a isopeptide bond between their C-terminal glycine and the ɛ-NH2 group of the target lysine residue.
Název v anglickém jazyce
Regulatory roles of sumoylation in messenger RNA processing and metabolism
Popis výsledku anglicky
Author discusses how the addition of the poly(A) tail of 30-100 adenosines to the 3´-end of mRNA has been shown to be important for the stability, nuclear export, export of mRNA to the cytoplasm and translation of a transcript. The molecular mechanism responsible for the definition of a poly(A) site includes several recognition, cleavage and polyadenylation factors that identify the poly(A) signal, usually AAUAAA hexamer and similar variants, located 10-35 nucleotides upstream of the cleavage site. The process known as SUMO (small ubiquitin-related modifier) conjugation to a lysine residue in the target protein or sumoylation is a rapid, reversible post-transcriptional modification is also examined. Similar to ubiquitin, SUMO isoforms are conjugated to their targets by a isopeptide bond between their C-terminal glycine and the ɛ-NH2 group of the target lysine residue.
Klasifikace
Druh
C - Kapitola v odborné knize
CEP obor
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OECD FORD obor
30205 - Hematology
Návaznosti výsledku
Projekt
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Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název knihy nebo sborníku
mRNA: molecular biology, processing and function
ISBN
978-1-53613-168-0
Počet stran výsledku
27
Strana od-do
69-96
Počet stran knihy
152
Název nakladatele
Nova Science
Místo vydání
New York
Kód UT WoS kapitoly
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Druh výsledku
C - Kapitola v odborné knize
OECD FORD
Hematology
Rok uplatnění
2018