Chimerism as an important marker in post-transplant monitoring chimerism monitoring

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F18%3A00012485" target="_blank" >RIV/00023736:_____/18:00012485 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1111/tan.13407" target="_blank" >https://doi.org/10.1111/tan.13407</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/tan.13407" target="_blank" >10.1111/tan.13407</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chimerism as an important marker in post-transplant monitoring chimerism monitoring

Popis výsledku v původním jazyce

Cell chimerism determination is important for the monitoring of engraftment dynamics and for relapse prediction. Our cohort of 474 patients was divided into two groups according to the determination methods used over time, and by their chimerism status. A significant difference in survival was observed between mixed vs complete chimerism (P < 0.0001 vs P < 0.0002) in both patient groups, and also vs microchimerism (P = 0.0201) in the second group. Detection of mixed chimerism is thus a high-risk factor, and microchimerism is potentially a risk factor in the post-transplantation course. Methods with a high sensitivity for monitoring cell chimerism significantly improve the assessment of patients post-transplant, and they enable the identification of patients with high relapse risk.

Název v anglickém jazyce

Chimerism as an important marker in post-transplant monitoring chimerism monitoring

Popis výsledku anglicky

Cell chimerism determination is important for the monitoring of engraftment dynamics and for relapse prediction. Our cohort of 474 patients was divided into two groups according to the determination methods used over time, and by their chimerism status. A significant difference in survival was observed between mixed vs complete chimerism (P < 0.0001 vs P < 0.0002) in both patient groups, and also vs microchimerism (P = 0.0201) in the second group. Detection of mixed chimerism is thus a high-risk factor, and microchimerism is potentially a risk factor in the post-transplantation course. Methods with a high sensitivity for monitoring cell chimerism significantly improve the assessment of patients post-transplant, and they enable the identification of patients with high relapse risk.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

HLA

ISSN

2059-2302

e-ISSN

—

Svazek periodika

92

Číslo periodika v rámci svazku

S2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

60-63

Kód UT WoS článku

000454095400008

EID výsledku v databázi Scopus

2-s2.0-85058887670