Targeted volatolomics of human monocytes: comparison of 2D-GC/TOF-MS and 1D-GC/Orbitrap-MS methods

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F21%3A00013292" target="_blank" >RIV/00023736:_____/21:00013292 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26620/21:PU142159 RIV/61388955:_____/21:00549181 RIV/00159816:_____/21:00075074 RIV/62156489:43210/21:43920397 RIV/62156489:43410/21:43920397

Výsledek na webu

<a href="https://doi.org/10.1016/j.jchromb.2021.122975" target="_blank" >https://doi.org/10.1016/j.jchromb.2021.122975</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jchromb.2021.122975" target="_blank" >10.1016/j.jchromb.2021.122975</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Targeted volatolomics of human monocytes: comparison of 2D-GC/TOF-MS and 1D-GC/Orbitrap-MS methods

Popis výsledku v původním jazyce

Blood is a complex biological matrix providing valuable information on nutritional, metabolic, and immune status. The detection of blood biomarkers requires sensitive analytical methods because analytes are at very low concentrations. Peripheral blood monocytes play a crucial role in inflammatory processes, and the metabolites released by monocytes during these processes might serve as important signalling molecules and biomarkers of particular physiological states. Headspace solid-phase microextraction (HS-SPME) combined with two different mass spectrometric platforms, two-dimensional (2D) gas chromatography coupled to time-of-flight mass spectrometry (2D-GC/TOF-MS) and one-dimensional gas chromatography coupled to Orbitrap mass spectrometry (GC/Orbitrap-MS), were applied for the investigation of volatile organic compounds (VOCs) produced by human peripheral blood monocytes.

Název v anglickém jazyce

Targeted volatolomics of human monocytes: comparison of 2D-GC/TOF-MS and 1D-GC/Orbitrap-MS methods

Popis výsledku anglicky

Blood is a complex biological matrix providing valuable information on nutritional, metabolic, and immune status. The detection of blood biomarkers requires sensitive analytical methods because analytes are at very low concentrations. Peripheral blood monocytes play a crucial role in inflammatory processes, and the metabolites released by monocytes during these processes might serve as important signalling molecules and biomarkers of particular physiological states. Headspace solid-phase microextraction (HS-SPME) combined with two different mass spectrometric platforms, two-dimensional (2D) gas chromatography coupled to time-of-flight mass spectrometry (2D-GC/TOF-MS) and one-dimensional gas chromatography coupled to Orbitrap mass spectrometry (GC/Orbitrap-MS), were applied for the investigation of volatile organic compounds (VOCs) produced by human peripheral blood monocytes.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of chromatography B: analytical technologies in the biomedical and life sciences

ISSN

1570-0232

e-ISSN

—

Svazek periodika

1184

Číslo periodika v rámci svazku

[November]

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

"art. no. 122975"

Kód UT WoS článku

000710634000005

EID výsledku v databázi Scopus

2-s2.0-85118774008