Applicability of gene expression in saliva as an alternative to blood for biodosimetry and prediction of radiation-inducede health effects

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F24%3A00013665" target="_blank" >RIV/00023736:_____/24:00013665 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1667/RADE-23-00176.1" target="_blank" >https://doi.org/10.1667/RADE-23-00176.1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1667/RADE-23-00176.1" target="_blank" >10.1667/RADE-23-00176.1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Applicability of gene expression in saliva as an alternative to blood for biodosimetry and prediction of radiation-inducede health effects

Popis výsledku v původním jazyce

As the great majority of gene expression (GE) biodosimetry studies have been performed using blood as the preferred source of tissue, searching for simple and less-invasive sampling methods is important when considering biodosimetry approaches. Knowing that whole saliva contains an ultrafiltrate of blood and white blood cells, it is expected that the findings in blood can also be found in saliva. This human in vivo study aims to examine radiation-induced GE changes in saliva for biodosimetry purposes and to predict radiation-induced disease, which is yet poorly characterized. Furthermore, we examined whether transcriptional biomarkers in blood can also be found equivalently in saliva.

Název v anglickém jazyce

Applicability of gene expression in saliva as an alternative to blood for biodosimetry and prediction of radiation-inducede health effects

Popis výsledku anglicky

As the great majority of gene expression (GE) biodosimetry studies have been performed using blood as the preferred source of tissue, searching for simple and less-invasive sampling methods is important when considering biodosimetry approaches. Knowing that whole saliva contains an ultrafiltrate of blood and white blood cells, it is expected that the findings in blood can also be found in saliva. This human in vivo study aims to examine radiation-induced GE changes in saliva for biodosimetry purposes and to predict radiation-induced disease, which is yet poorly characterized. Furthermore, we examined whether transcriptional biomarkers in blood can also be found equivalently in saliva.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Radiation research

ISSN

0033-7587

e-ISSN

—

Svazek periodika

201

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

523-534

Kód UT WoS článku

001226507700017

EID výsledku v databázi Scopus

2-s2.0-85192675519