Clonal hematopoiesis as a predictor of subsequent myeloid cancers

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Clonal hematopoiesis as a predictor of subsequent myeloid cancers

Popis výsledku v původním jazyce

Myeloid neoplasms including myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) originate from hematopoietic stem cells through the process known as clonal hematopoiesis. This process is characterized by the sequential acquisition of genetic and epigenetic alterations associated with impaired differentiation and increased proliferation. Myeloid neoplasms frequently develop from premalignant precursors that are detectable in many healthy individuals. These precursor states, such as clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenias of undetermined significance (CCUS), could allow earlier diagnosis of MDS. Clonal hematopoiesis in healthy persons and patients undergoing chemotherapy for non-hematologic cancer, and in autologous and allogeneic stem cell transplantation could be identified.

Název v anglickém jazyce

Clonal hematopoiesis as a predictor of subsequent myeloid cancers

Popis výsledku anglicky

Myeloid neoplasms including myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) originate from hematopoietic stem cells through the process known as clonal hematopoiesis. This process is characterized by the sequential acquisition of genetic and epigenetic alterations associated with impaired differentiation and increased proliferation. Myeloid neoplasms frequently develop from premalignant precursors that are detectable in many healthy individuals. These precursor states, such as clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenias of undetermined significance (CCUS), could allow earlier diagnosis of MDS. Clonal hematopoiesis in healthy persons and patients undergoing chemotherapy for non-hematologic cancer, and in autologous and allogeneic stem cell transplantation could be identified.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

30205 - Hematology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Advances in genetics research: volume 22

ISBN

979-8-89113-693-9

Počet stran výsledku

22

Strana od-do

67-88

Počet stran knihy

259

Název nakladatele

Nova Science

Místo vydání

New York

Kód UT WoS kapitoly

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