A short retrospective cytometric note on myeloblasts in patients suffering from acute myeloblastic leukaemia, myelodysplastic syndrome and chronic myelocytic leukaemia: myeloblasts with a narrow cytoplasm without azurophilic granules are less differentiated committed progenitor stem cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F24%3A00013760" target="_blank" >RIV/00023736:_____/24:00013760 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.14712/fb2024070050270" target="_blank" >https://doi.org/10.14712/fb2024070050270</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14712/fb2024070050270" target="_blank" >10.14712/fb2024070050270</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A short retrospective cytometric note on myeloblasts in patients suffering from acute myeloblastic leukaemia, myelodysplastic syndrome and chronic myelocytic leukaemia: myeloblasts with a narrow cytoplasm without azurophilic granules are less differentiated committed progenitor stem cells

Popis výsledku v původním jazyce

The maximal nuclear and cell body diameters of leukaemic agranular myeloblasts (type 1 without azurophilic granules) were measured in bone marrow smears of patients suffering from acute myeloblastic leukaemia with minimal differentiation (M0 AML), without and with maturation (M1 and M2 AML), refractory anaemia with excess of myeloblasts (RAEB) and chronic phase of the myeloid leukaemia (CML) to provide more information on the cytoplasmic space estimate occupied by the nucleus. The largest size of the cytoplasmic space occupied by the nucleus in agranular myeloblasts was noted in M0 and M1 AML in comparison with M2 AML or RAEB, and especially with CML. Similarly, agranular myeloblasts with nuclear bodies occupying more than 90 per cent of the cell space were most frequent in M0 and M1 AML (&gt 50 %), less frequent in M2 and RAEB (~ 20 %) but very rare in CML (~ 5 %). According to electron microscopy, the very narrow cytoplasmic shell surrounding the nucleus in such myeloblasts did not possess any space for structural components characteristic of the granulocytic cell lineage. Thus, the basic morphology of these myeloblasts would correspond to morphological features of a less differentiated committed stem cell. It should be noted that such cells may be easily recognized in currently stained bone marrow or peripheral blood smears.

Název v anglickém jazyce

A short retrospective cytometric note on myeloblasts in patients suffering from acute myeloblastic leukaemia, myelodysplastic syndrome and chronic myelocytic leukaemia: myeloblasts with a narrow cytoplasm without azurophilic granules are less differentiated committed progenitor stem cells

Popis výsledku anglicky

The maximal nuclear and cell body diameters of leukaemic agranular myeloblasts (type 1 without azurophilic granules) were measured in bone marrow smears of patients suffering from acute myeloblastic leukaemia with minimal differentiation (M0 AML), without and with maturation (M1 and M2 AML), refractory anaemia with excess of myeloblasts (RAEB) and chronic phase of the myeloid leukaemia (CML) to provide more information on the cytoplasmic space estimate occupied by the nucleus. The largest size of the cytoplasmic space occupied by the nucleus in agranular myeloblasts was noted in M0 and M1 AML in comparison with M2 AML or RAEB, and especially with CML. Similarly, agranular myeloblasts with nuclear bodies occupying more than 90 per cent of the cell space were most frequent in M0 and M1 AML (&gt 50 %), less frequent in M2 and RAEB (~ 20 %) but very rare in CML (~ 5 %). According to electron microscopy, the very narrow cytoplasmic shell surrounding the nucleus in such myeloblasts did not possess any space for structural components characteristic of the granulocytic cell lineage. Thus, the basic morphology of these myeloblasts would correspond to morphological features of a less differentiated committed stem cell. It should be noted that such cells may be easily recognized in currently stained bone marrow or peripheral blood smears.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Folia biologica

ISSN

0015-5500

e-ISSN

—

Svazek periodika

70

Číslo periodika v rámci svazku

5-6

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

4

Strana od-do

270-273

Kód UT WoS článku

001416039300004

EID výsledku v databázi Scopus

2-s2.0-85217624017