Novel antipsychotics: hopes and limitations

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Novel antipsychotics: hopes and limitations

Popis výsledku v původním jazyce

The last decade has been an era of a thrilling development of new antipsychotic drugs. These novel antipsychotics, also called "atypical", have a different mechanism of action from the conventional neuroleptics. They are characterized by a lower affinityto dopaminergic D2 receptors and a relatively high affinity to the serotoninergic system. In addition to their potent efficacy on positive psychotic symptoms which is comparable to that of the antidopaminergic drugs, they can improve negative, and possibly also affective and cognitive symptoms. Novel antipsychotics are associated with a low incidence of extrapyramidal side effects and tardive dyskinesia; this fact can assure better compliance. A prototype of this class is clozapine, a drug with well documented side effects and efficacy in treatment-resistant patients. Despite the growing number of publications and data on other novel drugs (risperidone, olanzapine, quetiapine), there is a lack of knowledge on effects in more specific p

Název v anglickém jazyce

Novel antipsychotics: hopes and limitations

Popis výsledku anglicky

The last decade has been an era of a thrilling development of new antipsychotic drugs. These novel antipsychotics, also called "atypical", have a different mechanism of action from the conventional neuroleptics. They are characterized by a lower affinityto dopaminergic D2 receptors and a relatively high affinity to the serotoninergic system. In addition to their potent efficacy on positive psychotic symptoms which is comparable to that of the antidopaminergic drugs, they can improve negative, and possibly also affective and cognitive symptoms. Novel antipsychotics are associated with a low incidence of extrapyramidal side effects and tardive dyskinesia; this fact can assure better compliance. A prototype of this class is clozapine, a drug with well documented side effects and efficacy in treatment-resistant patients. Despite the growing number of publications and data on other novel drugs (risperidone, olanzapine, quetiapine), there is a lack of knowledge on effects in more specific p

Druh

C - Kapitola v odborné knize

CEP obor

FL - Psychiatrie, sexuologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2000

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

5th Congress of the European Society for Clinical Neuropsychopharmacology, Opatija (Croatie), May 17 - 21, 2000

ISBN

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Počet stran výsledku

6

Strana od-do

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Počet stran knihy

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Název nakladatele

Monduzzi Editore

Místo vydání

Bologna

Kód UT WoS kapitoly

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