Characterisation of hippocampal neurodegeneration after intracerebroventricular administration of n-acetyl-aspartyl-glutamate

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F01%3A00000162" target="_blank" >RIV/00023752:_____/01:00000162 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Characterisation of hippocampal neurodegeneration after intracerebroventricular administration of n-acetyl-aspartyl-glutamate

Popis výsledku v původním jazyce

N-Acetyl-aspartyl-glutamate (NAAG), the most abundant neuroactive peptide in the mammalian CNS, has only two known specific targets in brain tissue: ionotropic glutamate receptor of N-methyl-D-aspartate type and metabotropic G-protein linked glutamate receptors of class II. Several observations have pointed to a nexus between changes in the level of NAAG in brain and the development of neurodegenerative and mental diseases. The precise role of NAAG in neurodegeneration (or in healthy brain tissue) is, however, less clear. There could be a fine balance between the neuroprotective and neurotoxic actions of NAAG, depending on which one of the two populations of receptors targeted by NAAG is more active. The decisive factor could be the extracellular concentration (rather than overall tissue level) of NAAG and this can be manipulated in an animal model in vivo. Therefore, we have been using quantitative morphology, electron microscopy and molecular biological techniques to study and charac

Název v anglickém jazyce

Characterisation of hippocampal neurodegeneration after intracerebroventricular administration of n-acetyl-aspartyl-glutamate

Popis výsledku anglicky

N-Acetyl-aspartyl-glutamate (NAAG), the most abundant neuroactive peptide in the mammalian CNS, has only two known specific targets in brain tissue: ionotropic glutamate receptor of N-methyl-D-aspartate type and metabotropic G-protein linked glutamate receptors of class II. Several observations have pointed to a nexus between changes in the level of NAAG in brain and the development of neurodegenerative and mental diseases. The precise role of NAAG in neurodegeneration (or in healthy brain tissue) is, however, less clear. There could be a fine balance between the neuroprotective and neurotoxic actions of NAAG, depending on which one of the two populations of receptors targeted by NAAG is more active. The decisive factor could be the extracellular concentration (rather than overall tissue level) of NAAG and this can be manipulated in an animal model in vivo. Therefore, we have been using quantitative morphology, electron microscopy and molecular biological techniques to study and charac

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/LN00B122" target="_blank" >LN00B122: Centrum neuropsychiatrických studií</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2001

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Psychiatrie

ISSN

1211-7579

e-ISSN

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Svazek periodika

5

Číslo periodika v rámci svazku

Suppl. 2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

3

Strana od-do

102-104

Kód UT WoS článku

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EID výsledku v databázi Scopus

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