Functional magnetic resonance (fMR) and serotonergic activity in the brain

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F02%3A00000246" target="_blank" >RIV/00023752:_____/02:00000246 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Functional magnetic resonance (fMR) and serotonergic activity in the brain

Popis výsledku v původním jazyce

The aim of our study was to elucidate the relationship between central serotonergic activity and the outcome in cognitive testing within the framework of functional activity in the relevant brain regions. The interaction between serotonine and dopamine within mesolimbic and mesocortical areas probably represents the basic substrate for pathophysiology and therapy of schizophrenia. Methods: Tryptophan depletion method (in comparison with placebo) was used as the probe to the role of serotonine in cognition. Tryptophan is the precursor of serotonine and the tryptophan depletion decreases rapidly the level of brain serotonine. Functional Magnetic Resonance (fMR) is a sophisticated non-invasive neuroimaging method enabling to measure regional cerebral blood flow and elaborate dynamic functional maps of brain activity. fMR was used to detect the changes in neuronal activation in the brain with respect to different level of serotonergic transmission. Results: In the group of 20 healthy subje

Název v anglickém jazyce

Functional magnetic resonance (fMR) and serotonergic activity in the brain

Popis výsledku anglicky

The aim of our study was to elucidate the relationship between central serotonergic activity and the outcome in cognitive testing within the framework of functional activity in the relevant brain regions. The interaction between serotonine and dopamine within mesolimbic and mesocortical areas probably represents the basic substrate for pathophysiology and therapy of schizophrenia. Methods: Tryptophan depletion method (in comparison with placebo) was used as the probe to the role of serotonine in cognition. Tryptophan is the precursor of serotonine and the tryptophan depletion decreases rapidly the level of brain serotonine. Functional Magnetic Resonance (fMR) is a sophisticated non-invasive neuroimaging method enabling to measure regional cerebral blood flow and elaborate dynamic functional maps of brain activity. fMR was used to detect the changes in neuronal activation in the brain with respect to different level of serotonergic transmission. Results: In the group of 20 healthy subje

Druh

D - Stať ve sborníku

CEP obor

FL - Psychiatrie, sexuologie

OECD FORD obor

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Projekt

<a href="/cs/project/NF6033" target="_blank" >NF6033: Porucha kognitivních funkcí u schizofrenie a centrální serotoninergní aktivita</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2002

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

X. International Congress of the Czech and Slovak Neurochemical Society, Casta, Slovakia, June 1-5, 2002

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

19

Název nakladatele

SAP - Slovak Academic Press

Místo vydání

Bratislava

Místo konání akce

Častá

Datum konání akce

1. 6. 2002

Typ akce podle státní příslušnosti

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Kód UT WoS článku

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