Functional glutamate receptors are expressed in rat brain capillary barrier

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F03%3A00000322" target="_blank" >RIV/00023752:_____/03:00000322 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Functional glutamate receptors are expressed in rat brain capillary barrier

Popis výsledku v původním jazyce

Glutamate, a major excitatory neurotransmitter, exerts a direct effect on cerebral capillary barrier, a structure that is characterized by high-resistance endothelial tight junctions, minimal endothelial pinocytosis and investment of the brain surface ofthe endothelium by astrocytic processes. We demonstrated that rat brain capillaries possess functional glutamate receptors of NMDA-type (and also AMPA-type and mGluR 1). Therefore, quinolinic acid (QUIN; an endogenous agonist of NMDA receptors), that isformed in retrovirus-infected perivascular microphages and microglia from tryptophan, may influence permeability of the rat brain capillary barrier by lipid peroxidation (determined as total lipid fluorescent products). Substances, exhibiting both an antagonist action on the NMDA receptors and antioxidant properties, can prevent the QUIN-induced lipid peroxidation in isolated rat brain microvessels. Involvement of glutamate receptors in the BBB dysfunction (presumed in some neuropsychia

Název v anglickém jazyce

Functional glutamate receptors are expressed in rat brain capillary barrier

Popis výsledku anglicky

Glutamate, a major excitatory neurotransmitter, exerts a direct effect on cerebral capillary barrier, a structure that is characterized by high-resistance endothelial tight junctions, minimal endothelial pinocytosis and investment of the brain surface ofthe endothelium by astrocytic processes. We demonstrated that rat brain capillaries possess functional glutamate receptors of NMDA-type (and also AMPA-type and mGluR 1). Therefore, quinolinic acid (QUIN; an endogenous agonist of NMDA receptors), that isformed in retrovirus-infected perivascular microphages and microglia from tryptophan, may influence permeability of the rat brain capillary barrier by lipid peroxidation (determined as total lipid fluorescent products). Substances, exhibiting both an antagonist action on the NMDA receptors and antioxidant properties, can prevent the QUIN-induced lipid peroxidation in isolated rat brain microvessels. Involvement of glutamate receptors in the BBB dysfunction (presumed in some neuropsychia

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NF7626" target="_blank" >NF7626: Hladiny mozkového glutamátu a podjednotková stavba glutamátového receptoru NMDA typu u schizofrenie: experimentálně - klinická studie.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Psychiatrie

ISSN

1211-7579

e-ISSN

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Svazek periodika

7

Číslo periodika v rámci svazku

Suppl. 2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

2

Strana od-do

127-128

Kód UT WoS článku

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EID výsledku v databázi Scopus

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