Monotherapie antidepresivy u pre-bipolární deprese: prediktivní hodnota a rizika

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F08%3A00000784" target="_blank" >RIV/00023752:_____/08:00000784 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Antidepressant monotherapy in pre-bipolar depression; predictive value and inherent risk

Popis výsledku v původním jazyce

Objective: To identify specific treatment-emergent symptoms in response to antidepressant therapy in depression preceding bipolar disorder. Methods: Retrospective chart review of response to antidepressants in ?pre-bipolar? depression, compared to amatched unipolar sample. Results: Family history of completed suicide (p=0.0003) and bipolar disorder (p=0.004) were more common in the pre-bipolar subgroup. Earlier age of onset of diagnosed depression (p=0.005) as well as even earlier episodes of untreatedretrospectively diagnosed major depression (pb0.0001) were associated with a future bipolar course. The pre-bipolar group was less likely to respond to antidepressant treatment (p=0.009). Treatment-emergent ?mixed? symptoms (two or more symptoms of DSM IV mania, mood lability, irritability/rage with co-existing depression) and in particular, ?serious symptoms? (treatment emergent or increased agitation, rage or suicidality) occurred more commonly in the bipolar group. The two variables t

Název v anglickém jazyce

Antidepressant monotherapy in pre-bipolar depression; predictive value and inherent risk

Popis výsledku anglicky

Objective: To identify specific treatment-emergent symptoms in response to antidepressant therapy in depression preceding bipolar disorder. Methods: Retrospective chart review of response to antidepressants in ?pre-bipolar? depression, compared to amatched unipolar sample. Results: Family history of completed suicide (p=0.0003) and bipolar disorder (p=0.004) were more common in the pre-bipolar subgroup. Earlier age of onset of diagnosed depression (p=0.005) as well as even earlier episodes of untreatedretrospectively diagnosed major depression (pb0.0001) were associated with a future bipolar course. The pre-bipolar group was less likely to respond to antidepressant treatment (p=0.009). Treatment-emergent ?mixed? symptoms (two or more symptoms of DSM IV mania, mood lability, irritability/rage with co-existing depression) and in particular, ?serious symptoms? (treatment emergent or increased agitation, rage or suicidality) occurred more commonly in the bipolar group. The two variables t

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FL - Psychiatrie, sexuologie

OECD FORD obor

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Projekt

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Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Affective Disorders

ISSN

0165-0327

e-ISSN

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Svazek periodika

107

Číslo periodika v rámci svazku

1-3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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