Avidity of antibodies against tau protein in patients with multiple sclerosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F09%3A00001018" target="_blank" >RIV/00023752:_____/09:00001018 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/09:5085

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Avidity of antibodies against tau protein in patients with multiple sclerosis

Popis výsledku v původním jazyce

Background: The low-molecular-weight tau protein belongs to the microtubule-associated proteins abundantly present in the central nervous system and expressed predominantly in axons (1). The function of these phosphoproteins is associated with the neuronal cytoskeleton. Tau stabilizes microtubules and promotes their polymerization (1). Some neurological diseases of the CNS include axonal injury. Multiple sclerosis (MS) is one of the disorders in whose pathogenesis the axonal damage is involved (2). Several cytoskeletal structures have been explored to reflect this event. Tubulin, neurofilaments, actin or tau proteins were examined as markers of the axonal damage (3, 4). During this process cytoskeletal structures are released into the extracellular environment, where the synthesis of specific antibodies may be induced (5, 6). It was observed that immunization of mice by the recombinant tau protein induced the synthesis of anti-tau antibodies. Moreover, these specific anti-tau antibodie

Název v anglickém jazyce

Avidity of antibodies against tau protein in patients with multiple sclerosis

Popis výsledku anglicky

Background: The low-molecular-weight tau protein belongs to the microtubule-associated proteins abundantly present in the central nervous system and expressed predominantly in axons (1). The function of these phosphoproteins is associated with the neuronal cytoskeleton. Tau stabilizes microtubules and promotes their polymerization (1). Some neurological diseases of the CNS include axonal injury. Multiple sclerosis (MS) is one of the disorders in whose pathogenesis the axonal damage is involved (2). Several cytoskeletal structures have been explored to reflect this event. Tubulin, neurofilaments, actin or tau proteins were examined as markers of the axonal damage (3, 4). During this process cytoskeletal structures are released into the extracellular environment, where the synthesis of specific antibodies may be induced (5, 6). It was observed that immunization of mice by the recombinant tau protein induced the synthesis of anti-tau antibodies. Moreover, these specific anti-tau antibodie

Druh

D - Stať ve sborníku

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NS10369" target="_blank" >NS10369: Využití neurocytoskeletálních proteinů a protilátek proti nim v diagnostice Alzheimerovy nemoci</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

From Pathogenesis to Therapy of Autoimmune Diseases. Autoantigens, Autoantibodies, Autoimmunity

ISBN

978-3-89967-579-5

ISSN

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e-ISSN

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Počet stran výsledku

3

Strana od-do

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Název nakladatele

Pabst Science Publishers

Místo vydání

Dresden

Místo konání akce

Dresden

Datum konání akce

2. 9. 2009

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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