Altered levels of circulating GABAergic 5?/?-reduced pregnane and androstane steroids in schizophrenic men

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F11%3A00001210" target="_blank" >RIV/00023752:_____/11:00001210 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1515/hmbci.2010.083" target="_blank" >http://dx.doi.org/10.1515/hmbci.2010.083</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/hmbci.2010.083" target="_blank" >10.1515/hmbci.2010.083</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Altered levels of circulating GABAergic 5?/?-reduced pregnane and androstane steroids in schizophrenic men

Popis výsledku v původním jazyce

The role of GABAergic pathways in the pathophysiology of schizophrenia is generally accepted. Therefore, the information concerning alterations of the steroid metabolome associated with the disease and/or its treatment is of interest with regard to the pathophysiology of the disease. Hence, we assessed 18 serum steroids and steroid polar conjugates in a group of drug-naive patients (13 adult men) and after 6-months therapy by atypical antipsychotics and age-matched controls (19 men) using gas chromatography-mass spectrometry analysis. This study, for the first time, demonstrates the altered circulating GABAergic steroids in schizophrenic men as well as the effect of the therapy with two types of atypical antipsychotics. The GABAergic androsterone (3?5?) and etiocholanolone (3?5?) are reduced in schizophrenic men but the therapy with atypical antipsychotics reinstates their levels. This reinstatement could be of importance when considering that the GABAergic substances generally improve

Název v anglickém jazyce

Altered levels of circulating GABAergic 5?/?-reduced pregnane and androstane steroids in schizophrenic men

Popis výsledku anglicky

The role of GABAergic pathways in the pathophysiology of schizophrenia is generally accepted. Therefore, the information concerning alterations of the steroid metabolome associated with the disease and/or its treatment is of interest with regard to the pathophysiology of the disease. Hence, we assessed 18 serum steroids and steroid polar conjugates in a group of drug-naive patients (13 adult men) and after 6-months therapy by atypical antipsychotics and age-matched controls (19 men) using gas chromatography-mass spectrometry analysis. This study, for the first time, demonstrates the altered circulating GABAergic steroids in schizophrenic men as well as the effect of the therapy with two types of atypical antipsychotics. The GABAergic androsterone (3?5?) and etiocholanolone (3?5?) are reduced in schizophrenic men but the therapy with atypical antipsychotics reinstates their levels. This reinstatement could be of importance when considering that the GABAergic substances generally improve

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FL - Psychiatrie, sexuologie

OECD FORD obor

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Projekt

<a href="/cs/project/NS9835" target="_blank" >NS9835: Úloha neuroaktivních steroidů a dalších hormonálních ukazatelů v diagnostice a léčbě schizofrenie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Hormone Molecular Biology and Clinical Investigation

ISSN

1868-1891

e-ISSN

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Svazek periodika

6

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

4

Strana od-do

227-230

Kód UT WoS článku

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EID výsledku v databázi Scopus

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