Adherence and long-acting injectable antipsychotics in schizophrenia: an update

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F12%3A43913824" target="_blank" >RIV/00023752:_____/12:43913824 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.5350/DAJPN20122504001" target="_blank" >http://dx.doi.org/10.5350/DAJPN20122504001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5350/DAJPN20122504001" target="_blank" >10.5350/DAJPN20122504001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Adherence and long-acting injectable antipsychotics in schizophrenia: an update

Popis výsledku v původním jazyce

Nonadherence to antipsychotics poses a major problem in the long-term management of schizophrenia. Subjective measures of adherence (self-reports, provider reports) are unreliable, more objective methods (e.g., electronic monitoring, plasma levels) are neither available in clinical practice, nor are they infallible. Risk factors include history of nonadherence, substance use, limited insight, treatment with antidepressants, medication-induced cognitive impairment, hostility, and violent behavior. Nonadherence results in partial or no response to antipsychotic treatment with many adverse consequences, including higher mortality. A recent meta-analysis somewhat surprisingly failed to prove higher adherence to long-acting injectable antipsychotics (LAI) than to oral antipsychotics. However, unexpectedly high adherence in the reviewed trials suggests selection bias. This is further supported indirectly by the findings from two large observational studies from Finland. They showed that LAI,

Název v anglickém jazyce

Adherence and long-acting injectable antipsychotics in schizophrenia: an update

Popis výsledku anglicky

Nonadherence to antipsychotics poses a major problem in the long-term management of schizophrenia. Subjective measures of adherence (self-reports, provider reports) are unreliable, more objective methods (e.g., electronic monitoring, plasma levels) are neither available in clinical practice, nor are they infallible. Risk factors include history of nonadherence, substance use, limited insight, treatment with antidepressants, medication-induced cognitive impairment, hostility, and violent behavior. Nonadherence results in partial or no response to antipsychotic treatment with many adverse consequences, including higher mortality. A recent meta-analysis somewhat surprisingly failed to prove higher adherence to long-acting injectable antipsychotics (LAI) than to oral antipsychotics. However, unexpectedly high adherence in the reviewed trials suggests selection bias. This is further supported indirectly by the findings from two large observational studies from Finland. They showed that LAI,

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FL - Psychiatrie, sexuologie

OECD FORD obor

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Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Dusunen Adam

ISSN

1309-5749

e-ISSN

—

Svazek periodika

25

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

TR - Turecká republika

Počet stran výsledku

12

Strana od-do

285-296

Kód UT WoS článku

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EID výsledku v databázi Scopus

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