Subcortical volumetric abnormalities in bipolar disorder

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F16%3A43915190" target="_blank" >RIV/00023752:_____/16:43915190 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.nature.com/mp/journal/vaop/ncurrent/full/mp2015227a.html" target="_blank" >http://www.nature.com/mp/journal/vaop/ncurrent/full/mp2015227a.html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/mp.2015.227" target="_blank" >10.1038/mp.2015.227</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Subcortical volumetric abnormalities in bipolar disorder

Popis výsledku v původním jazyce

Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying the sources of uncertainty can help generate novel clinical hypotheses about etiology and assist in the development of biomarkers for indexing disease progression and prognosis. Here we were interested in quantifying case-control differences in intracranial volume (ICV) and each of eight subcortical brain measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles. In a large study of 1710 BD patients and 2594 healthy controls, we found consistent volumetric reductions in BD patients for mean hippocampus (Cohen's d=MINUS SIGN 0.232; P=3.50 x 10MINUS SIGN 7) and thalamus (d=MINUS SIGN 0.148; P=4.27 x 10MINUS SIGN 3) and enlarged lateral ventricles (d=MINUS SIGN 0.260; P=3.93 x 10MINUS SIGN 5) in patients. No significant effect of age at illness onset was detected. Stratifying patients based on clinical subtype (BD type I or type II) revealed that BDI patients had significantly larger lateral ventricles and smaller hippocampus and amygdala than controls. However, when comparing BDI and BDII patients directly, we did not detect any significant differences in brain volume. This likely represents similar etiology between BD subtype classifications. Exploratory analyses revealed significantly larger thalamic volumes in patients taking lithium compared with patients not taking lithium. We detected no significant differences between BDII patients and controls in the largest such comparison to date. Findings in this study should be interpreted with caution and with careful consideration of the limitations inherent to meta-analyzed neuroimaging comparisons.

Název v anglickém jazyce

Subcortical volumetric abnormalities in bipolar disorder

Popis výsledku anglicky

Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying the sources of uncertainty can help generate novel clinical hypotheses about etiology and assist in the development of biomarkers for indexing disease progression and prognosis. Here we were interested in quantifying case-control differences in intracranial volume (ICV) and each of eight subcortical brain measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles. In a large study of 1710 BD patients and 2594 healthy controls, we found consistent volumetric reductions in BD patients for mean hippocampus (Cohen's d=MINUS SIGN 0.232; P=3.50 x 10MINUS SIGN 7) and thalamus (d=MINUS SIGN 0.148; P=4.27 x 10MINUS SIGN 3) and enlarged lateral ventricles (d=MINUS SIGN 0.260; P=3.93 x 10MINUS SIGN 5) in patients. No significant effect of age at illness onset was detected. Stratifying patients based on clinical subtype (BD type I or type II) revealed that BDI patients had significantly larger lateral ventricles and smaller hippocampus and amygdala than controls. However, when comparing BDI and BDII patients directly, we did not detect any significant differences in brain volume. This likely represents similar etiology between BD subtype classifications. Exploratory analyses revealed significantly larger thalamic volumes in patients taking lithium compared with patients not taking lithium. We detected no significant differences between BDII patients and controls in the largest such comparison to date. Findings in this study should be interpreted with caution and with careful consideration of the limitations inherent to meta-analyzed neuroimaging comparisons.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

AN - Psychologie

OECD FORD obor

—

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecular Psychiatry

ISSN

1359-4184

e-ISSN

—

Svazek periodika

21

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

1710-1716

Kód UT WoS článku

000388720600010

EID výsledku v databázi Scopus

2-s2.0-84995699210