A parsimonious scoring and normative calculator for the Parkinson’s disease mild cognitive impairment battery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F17%3A43915383" target="_blank" >RIV/00023752:_____/17:43915383 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/17:10363424 RIV/00064165:_____/17:10363424

Výsledek na webu

<a href="http://www.tandfonline.com/doi/citedby/10.1080/13854046.2017.1293161?scroll=top&needAccess=true" target="_blank" >http://www.tandfonline.com/doi/citedby/10.1080/13854046.2017.1293161?scroll=top&needAccess=true</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/13854046.2017.1293161" target="_blank" >10.1080/13854046.2017.1293161</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A parsimonious scoring and normative calculator for the Parkinson’s disease mild cognitive impairment battery

Popis výsledku v původním jazyce

Objective: The aim of the present study was to provide a regression-based calculator that takes premorbid functioning into account to detect subtle cognitive decline, as is often present in pre-dementia states, especially mild cognitive impairment in Parkinson’s disease (PD-MCI). Method: We used demographic adjustments based on sex, age, and education of 699 normative participants that fulfilled exclusion criteria for ascertaining the diagnostic accuracy of the Movement Disorders Society PD-MCI battery at Level II. We examined the clinical validity of the battery on 36 PD patients. Results: An estimated z-score was calculated for any raw score based on different models that adjust for the demographic predictors of gender, age, and education, either concurrently, individually or without covariates. We provide a useful online z-score, SD, and percentile calculator that yields estimates of cognitive impairment based on normative sample for each of the ten neuropsychological tests and enables actuarial decision-making regarding its level and profile (number of domains impaired). We document the clinical utility and applicability of the calculator on a patient with PD-MCI and show the discriminative validity of all measures in the battery by comparing PD-MCI and PD without cognitive impairment with the highest area under the curve (.94) for Tower of London at −2 SD threshold. Conclusions: Our normative calculator introduces a practical web-based psychometric tool for the evaluation of PD-MCI status in clinical settings. We show the detection potential of each of ten measures included in the battery and delineate the diagnostic precision of the PD-MCI battery.

Název v anglickém jazyce

A parsimonious scoring and normative calculator for the Parkinson’s disease mild cognitive impairment battery

Popis výsledku anglicky

Objective: The aim of the present study was to provide a regression-based calculator that takes premorbid functioning into account to detect subtle cognitive decline, as is often present in pre-dementia states, especially mild cognitive impairment in Parkinson’s disease (PD-MCI). Method: We used demographic adjustments based on sex, age, and education of 699 normative participants that fulfilled exclusion criteria for ascertaining the diagnostic accuracy of the Movement Disorders Society PD-MCI battery at Level II. We examined the clinical validity of the battery on 36 PD patients. Results: An estimated z-score was calculated for any raw score based on different models that adjust for the demographic predictors of gender, age, and education, either concurrently, individually or without covariates. We provide a useful online z-score, SD, and percentile calculator that yields estimates of cognitive impairment based on normative sample for each of the ten neuropsychological tests and enables actuarial decision-making regarding its level and profile (number of domains impaired). We document the clinical utility and applicability of the calculator on a patient with PD-MCI and show the discriminative validity of all measures in the battery by comparing PD-MCI and PD without cognitive impairment with the highest area under the curve (.94) for Tower of London at −2 SD threshold. Conclusions: Our normative calculator introduces a practical web-based psychometric tool for the evaluation of PD-MCI status in clinical settings. We show the detection potential of each of ten measures included in the battery and delineate the diagnostic precision of the PD-MCI battery.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

50101 - Psychology (including human - machine relations)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Neuropsychologist

ISSN

1385-4046

e-ISSN

—

Svazek periodika

31

Číslo periodika v rámci svazku

6-7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

17

Strana od-do

1231-1247

Kód UT WoS článku

000409318000018

EID výsledku v databázi Scopus

2-s2.0-85014440702