Subjective cognitive complaints in cognitively healthy older adults and their relation to cognitive performance and depressive symptoms

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F17%3A43915428" target="_blank" >RIV/00023752:_____/17:43915428 - isvavai.cz</a>

Výsledek na webu

<a href="http://content.iospress.com/articles/journal-of-alzheimers-disease/jad160970" target="_blank" >http://content.iospress.com/articles/journal-of-alzheimers-disease/jad160970</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3233/JAD-160970" target="_blank" >10.3233/JAD-160970</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Subjective cognitive complaints in cognitively healthy older adults and their relation to cognitive performance and depressive symptoms

Popis výsledku v původním jazyce

Background: Subjective cognitive complaints (SCCs) may be an early marker of prodromal Alzheimer´s disease. Objectives: Using a 10-item yes/no SCCs questionnaire (Le Questionnaire de Plainte Cognitive [QPC]), we evaluated the prevalence and distribution of SCCs in cognitively healthy Czech older adults and examined total score and specific QPC items in relation to depressive symptomology and cognitive performance. Methods: A sample of 340 cognitively healthy older community-dwelling volunteers aged 60 or older from the third wave of the longitudinal project National Normative Study of Cognitive Determinants of Healthy Aging, who underwent a comprehensive neuropsychological assessment and completed the QPC and the 15-item Geriatric Depression Scale (GDS-15). Regression analysis was controlled for age when GDS-15 was the outcome and for age and GDS-15 with cognitive domains as the outcome. Results: Seventy-one percent reported 1+ SCCs, with prevalence of individual complaints ranging from 4% to 40%. The number of SCCs was associated with GDS-15 (p&lt;0.001). &quot;Personality change&quot; (p&lt;0.001) and &quot;Limitation in daily activities&quot; (p=0.002) were significantly associated with higher GDS-15 score and &quot;Spatial orientation difficulties&quot; (p=0.019) and &quot;Impression of worse memory in comparison to peers&quot; (p=0.012) were significantly associated with lower memory performance. Conclusions: We identified some cognitive complaints that were very common in our sample. Overall, a higher number of SCCs in well cognitively functioning individuals was most closely related to depressive symptomatology, while some specific complaints reflected lower memory performance and should be considered when screening for people at risk of cognitive decline.

Název v anglickém jazyce

Subjective cognitive complaints in cognitively healthy older adults and their relation to cognitive performance and depressive symptoms

Popis výsledku anglicky

Background: Subjective cognitive complaints (SCCs) may be an early marker of prodromal Alzheimer´s disease. Objectives: Using a 10-item yes/no SCCs questionnaire (Le Questionnaire de Plainte Cognitive [QPC]), we evaluated the prevalence and distribution of SCCs in cognitively healthy Czech older adults and examined total score and specific QPC items in relation to depressive symptomology and cognitive performance. Methods: A sample of 340 cognitively healthy older community-dwelling volunteers aged 60 or older from the third wave of the longitudinal project National Normative Study of Cognitive Determinants of Healthy Aging, who underwent a comprehensive neuropsychological assessment and completed the QPC and the 15-item Geriatric Depression Scale (GDS-15). Regression analysis was controlled for age when GDS-15 was the outcome and for age and GDS-15 with cognitive domains as the outcome. Results: Seventy-one percent reported 1+ SCCs, with prevalence of individual complaints ranging from 4% to 40%. The number of SCCs was associated with GDS-15 (p&lt;0.001). &quot;Personality change&quot; (p&lt;0.001) and &quot;Limitation in daily activities&quot; (p=0.002) were significantly associated with higher GDS-15 score and &quot;Spatial orientation difficulties&quot; (p=0.019) and &quot;Impression of worse memory in comparison to peers&quot; (p=0.012) were significantly associated with lower memory performance. Conclusions: We identified some cognitive complaints that were very common in our sample. Overall, a higher number of SCCs in well cognitively functioning individuals was most closely related to depressive symptomatology, while some specific complaints reflected lower memory performance and should be considered when screening for people at risk of cognitive decline.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Alzheimer´s Disease

ISSN

1387-2877

e-ISSN

—

Svazek periodika

59

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

871-881

Kód UT WoS článku

000406926700006

EID výsledku v databázi Scopus

2-s2.0-85026797050