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Psychiatric disorders and quality of life in the offspring of parents with bipolar disorder

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F17%3A43918988" target="_blank" >RIV/00023752:_____/17:43918988 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00216208:11110/17:10363834 RIV/00216208:11120/17:43915288 RIV/00216208:11130/17:10363834 RIV/00064203:_____/17:10363834 RIV/00064165:_____/17:10363834

  • Výsledek na webu

    <a href="http://online.liebertpub.com/doi/10.1089/cap.2016.0056" target="_blank" >http://online.liebertpub.com/doi/10.1089/cap.2016.0056</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1089/cap.2016.0056" target="_blank" >10.1089/cap.2016.0056</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Psychiatric disorders and quality of life in the offspring of parents with bipolar disorder

  • Popis výsledku v původním jazyce

    Objective: To determine current and lifetime psychopathology and assess quality of life (QoL) in offspring of a parent with bipolar disorder (BD). Methods: We investigated 43 offspring of bipolar parents (high-risk offspring [HRO]) (mean age 12.5 – 3.1; range 6.7–17.9 years) and 43 comparison offspring matched for sex, age, and IQ of healthy parents. Lifetime and current presence of Diagnostic and Statistical Manual of Mental Disorders, 5th ed. (DSM-5) diagnoses were assessed using Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version (K-SADS-PL). We administered parent and self-report versions of General Behavior Inventory and the Screen for Child Anxiety-Related Emotional Disorders (SCARED). QoL was evaluated using the self-report questionnaire KIDSCREN-52. Results: Thirty-seven HRO (86%) and 18 controls (42%) met DSM-5 criteria for at least one lifetime psychiatric diagnosis (adjusted OR= 7.20; 95% CI 2.27–22.81). Compared to controls, HRO had higher lifetime frequency of any mood disorder (33% vs. 2%, p &lt; 0.001), anxiety disorder (60% vs. 14%, p &lt; 0.001), and attention-deficit/hyperactivity disorder (26% vs. 5%, p = 0.01). After adjustment for confounders, only mood (OR = 13.05; 95% CI 1.41–120.60) and anxiety (OR = 9.69; 95% CI 2.75–34.31) disorders remained significantly more frequent in the HRO group. In comparison with controls, HRO scored lower in the following domains: QoL, social support and relationship with peers ( p = 0.003; Cohen’s d = 0.91), parent relationships and home life ( p = 0.008; d = 0.67), as well as self-perception ( p = 0.04; d = 0.55). Conclusions: In agreement with other studies, we found a higher rate of lifetime anxiety and mood disorders in children and adolescents at confirmed familial risk for BD. Reduction in QoL was already evident across a number of domains. Adult psychiatrists should incorporate into their assessment procedures targeted questions on the presence of psychopathology in offspring of their adult patients with severe mental disorders and child services should bridge with adult services providing accessible services to children of affected parents.

  • Název v anglickém jazyce

    Psychiatric disorders and quality of life in the offspring of parents with bipolar disorder

  • Popis výsledku anglicky

    Objective: To determine current and lifetime psychopathology and assess quality of life (QoL) in offspring of a parent with bipolar disorder (BD). Methods: We investigated 43 offspring of bipolar parents (high-risk offspring [HRO]) (mean age 12.5 – 3.1; range 6.7–17.9 years) and 43 comparison offspring matched for sex, age, and IQ of healthy parents. Lifetime and current presence of Diagnostic and Statistical Manual of Mental Disorders, 5th ed. (DSM-5) diagnoses were assessed using Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version (K-SADS-PL). We administered parent and self-report versions of General Behavior Inventory and the Screen for Child Anxiety-Related Emotional Disorders (SCARED). QoL was evaluated using the self-report questionnaire KIDSCREN-52. Results: Thirty-seven HRO (86%) and 18 controls (42%) met DSM-5 criteria for at least one lifetime psychiatric diagnosis (adjusted OR= 7.20; 95% CI 2.27–22.81). Compared to controls, HRO had higher lifetime frequency of any mood disorder (33% vs. 2%, p &lt; 0.001), anxiety disorder (60% vs. 14%, p &lt; 0.001), and attention-deficit/hyperactivity disorder (26% vs. 5%, p = 0.01). After adjustment for confounders, only mood (OR = 13.05; 95% CI 1.41–120.60) and anxiety (OR = 9.69; 95% CI 2.75–34.31) disorders remained significantly more frequent in the HRO group. In comparison with controls, HRO scored lower in the following domains: QoL, social support and relationship with peers ( p = 0.003; Cohen’s d = 0.91), parent relationships and home life ( p = 0.008; d = 0.67), as well as self-perception ( p = 0.04; d = 0.55). Conclusions: In agreement with other studies, we found a higher rate of lifetime anxiety and mood disorders in children and adolescents at confirmed familial risk for BD. Reduction in QoL was already evident across a number of domains. Adult psychiatrists should incorporate into their assessment procedures targeted questions on the presence of psychopathology in offspring of their adult patients with severe mental disorders and child services should bridge with adult services providing accessible services to children of affected parents.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30215 - Psychiatry

Návaznosti výsledku

  • Projekt

    Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Ostatní

  • Rok uplatnění

    2017

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Journal of Child and Adolescent Psychopharmacology

  • ISSN

    1044-5463

  • e-ISSN

  • Svazek periodika

    27

  • Číslo periodika v rámci svazku

    6

  • Stát vydavatele periodika

    US - Spojené státy americké

  • Počet stran výsledku

    11

  • Strana od-do

    483-493

  • Kód UT WoS článku

    000407894800003

  • EID výsledku v databázi Scopus

    2-s2.0-85027885952