Synthetic aminoindanes: a summary of existing knowledge

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F17%3A43919035" target="_blank" >RIV/00023752:_____/17:43919035 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/17:43915969

Výsledek na webu

<a href="https://www.frontiersin.org/articles/10.3389/fpsyt.2017.00236/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fpsyt.2017.00236/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fpsyt.2017.00236" target="_blank" >10.3389/fpsyt.2017.00236</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthetic aminoindanes: a summary of existing knowledge

Popis výsledku v původním jazyce

Objectives: Aminoindanes (“bath salts”, a class of novel psychoactive substances, NPSs) increased rapidly in popularity on the recreational drug market, particularly after mephedrone and other synthetic cathinones were banned in the UK in 2010. Novel aminoindanes continue to emerge, but relatively little is known about their effects and risks. Their history, chemistry, pharmacology, behavioural effects, pharmacokinetics and toxicity are reviewed in this paper. Methods: Scientific literature was searched on ISI Web of Knowledge: Web of Science (WoS) during June and July 2017, using English language terms: aminoindane, MDAI, 5,6-methylenedioxy-2-aminoindane, 5-IAI, 5-Iodo-2-aminoindane, 2-aminoindane, MDMAI, 5,6-Methylenedioxy-N-methyl-2-aminoindane, MMAI, 5-Methoxy-6-methyl-2-aminoindane. WoS was selected as it searches several databases simultaneously and has quality criteria for inclusion. For typical use and effects Erowid, PsychonautWiki, Bluelight and Drugs-Forum were searched; for legal status and epidemiology, the European Information System and Database on New Drugs (EDND) was used. Results: Aminoindanes were first synthesized for medical use as e.g., as anti-Parkinsonian drugs and later as a potential compound facilitating psychotherapy, however they are now widely substituted for ecstasy. Their mechanisms of action (primarily via serotonin), mean that they may pose a significant risk of serotonin syndrome at high doses, or when combined with other drugs. Fatally toxic effects have been observed both in the laboratory in animal studies and in clinic, where aminoindanes-related deaths have been reported. Conclusion: Greater knowledge about aminoindanes is urgently required to decrease risks of fatal intoxication, and appropriate legislation is needed to protect public health without impeding research.

Název v anglickém jazyce

Synthetic aminoindanes: a summary of existing knowledge

Popis výsledku anglicky

Objectives: Aminoindanes (“bath salts”, a class of novel psychoactive substances, NPSs) increased rapidly in popularity on the recreational drug market, particularly after mephedrone and other synthetic cathinones were banned in the UK in 2010. Novel aminoindanes continue to emerge, but relatively little is known about their effects and risks. Their history, chemistry, pharmacology, behavioural effects, pharmacokinetics and toxicity are reviewed in this paper. Methods: Scientific literature was searched on ISI Web of Knowledge: Web of Science (WoS) during June and July 2017, using English language terms: aminoindane, MDAI, 5,6-methylenedioxy-2-aminoindane, 5-IAI, 5-Iodo-2-aminoindane, 2-aminoindane, MDMAI, 5,6-Methylenedioxy-N-methyl-2-aminoindane, MMAI, 5-Methoxy-6-methyl-2-aminoindane. WoS was selected as it searches several databases simultaneously and has quality criteria for inclusion. For typical use and effects Erowid, PsychonautWiki, Bluelight and Drugs-Forum were searched; for legal status and epidemiology, the European Information System and Database on New Drugs (EDND) was used. Results: Aminoindanes were first synthesized for medical use as e.g., as anti-Parkinsonian drugs and later as a potential compound facilitating psychotherapy, however they are now widely substituted for ecstasy. Their mechanisms of action (primarily via serotonin), mean that they may pose a significant risk of serotonin syndrome at high doses, or when combined with other drugs. Fatally toxic effects have been observed both in the laboratory in animal studies and in clinic, where aminoindanes-related deaths have been reported. Conclusion: Greater knowledge about aminoindanes is urgently required to decrease risks of fatal intoxication, and appropriate legislation is needed to protect public health without impeding research.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30215 - Psychiatry

Projekt

<a href="/cs/project/LO1611" target="_blank" >LO1611: Udržitelnost pro Národní ústav duševního zdraví</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Psychiatry

ISSN

1664-0640

e-ISSN

—

Svazek periodika

8

Číslo periodika v rámci svazku

November

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

"Article Number: 236"

Kód UT WoS článku

000415593400001

EID výsledku v databázi Scopus

2-s2.0-85034572487