Impairment of neural coordination in hippocampal neuronal ensembles after a psychotomimetic dose of dizocilpine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F18%3A43919060" target="_blank" >RIV/00023752:_____/18:43919060 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/18:00489341

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0278584617302464?via%3Dihub" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0278584617302464?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pnpbp.2017.09.013" target="_blank" >10.1016/j.pnpbp.2017.09.013</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Impairment of neural coordination in hippocampal neuronal ensembles after a psychotomimetic dose of dizocilpine

Popis výsledku v původním jazyce

The discoordination hypothesis of schizophrenia posits discoordination of neural activity as the central mechanism that underlies some psychotic symptoms (including ‘hallmark’ cognitive symptoms) of schizophrenia. To test this proposition, we studied the activity of hippocampal neurons in urethane anesthetized Long Evans rats after 0.15 mg/kg dizocilpine (MK-801), an N-Methyl-D-aspartate (NMDA) glutamate receptor antagonist, which can cause psychotic symptoms in humans and cognitive control impairments in animals. We observed that MK-801 altered the temporal coordination, but not rate, of neuronal firing. Coactivation between neurons increased, driven primarily by increased coincident firing of cell pairs that did not originally fire together before MK-801 injection. Increased pairwise coactivation manifested as disorganized discharge on the level of neuronal ensembles, which in turn could lead to disorganization in information processing. Disorganization of neuronal activity after a psychotomimetic dose of MK-801 supports the discoordination hypothesis of psychosis.

Název v anglickém jazyce

Impairment of neural coordination in hippocampal neuronal ensembles after a psychotomimetic dose of dizocilpine

Popis výsledku anglicky

The discoordination hypothesis of schizophrenia posits discoordination of neural activity as the central mechanism that underlies some psychotic symptoms (including ‘hallmark’ cognitive symptoms) of schizophrenia. To test this proposition, we studied the activity of hippocampal neurons in urethane anesthetized Long Evans rats after 0.15 mg/kg dizocilpine (MK-801), an N-Methyl-D-aspartate (NMDA) glutamate receptor antagonist, which can cause psychotic symptoms in humans and cognitive control impairments in animals. We observed that MK-801 altered the temporal coordination, but not rate, of neuronal firing. Coactivation between neurons increased, driven primarily by increased coincident firing of cell pairs that did not originally fire together before MK-801 injection. Increased pairwise coactivation manifested as disorganized discharge on the level of neuronal ensembles, which in turn could lead to disorganization in information processing. Disorganization of neuronal activity after a psychotomimetic dose of MK-801 supports the discoordination hypothesis of psychosis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Progress in Neuro-Psychopharmacology &amp; Biological Psychiatry

ISSN

0278-5846

e-ISSN

—

Svazek periodika

81

Číslo periodika v rámci svazku

February

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

275-283

Kód UT WoS článku

000414901100032

EID výsledku v databázi Scopus

2-s2.0-85029675626