Magnetic resonance imaging showing parietal atrophy of the brain in lateonset Alzheimer’s disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F19%3A43919809" target="_blank" >RIV/00023752:_____/19:43919809 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.csnn.eu/casopisy/ceska-slovenska-neurologie/2019-1-2/parietalni-atrofie-na-magneticke-rezonanci-mozku-u-alzheimerovy-nemoci-s-pozdnim-zacatkem-107572" target="_blank" >https://www.csnn.eu/casopisy/ceska-slovenska-neurologie/2019-1-2/parietalni-atrofie-na-magneticke-rezonanci-mozku-u-alzheimerovy-nemoci-s-pozdnim-zacatkem-107572</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14735/amcsnn201991" target="_blank" >10.14735/amcsnn201991</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Magnetic resonance imaging showing parietal atrophy of the brain in lateonset Alzheimer’s disease

Popis výsledku v původním jazyce

Aim: Our intention was to assess whether a scoring of parietal atrophy on MRI of the brain using a simple visual assessment named PAS (Parietal Atrophy Score) could be used in the diagnosis of late-onset Alzheimer‘s disease. Patients and methods: The structure of the parietal lobes was evaluated by our visual scale named PAS, which is based on semiquantitative scoring of atrophy of three structures in the parietal region: sulcus cingularis posterior, precuneus and parietal gyri. Parietal atrophy was assessed in 24 patients with late-onset Alzheimer‘s disease in the stage of mild dementia (Mini-Mental State Examination; MMSE 21 ± 3 points) and 26 age-matched individuals with normal scores on the MMSE (29 ± 1 point). Results: We did not find any statistically significant difference in the size of any structure of the right and left parietal lobe according to the PAS visual scale between control individuals and patients with Alzheimer‘s disease (p &gt; 0.05 in all cases). Conclusion: During late-onset Alzheimer‘s disease there is no significant reduction of parietal cortex until the stage of mild dementia compared to normal aging. Parietal atrophy evaluated according to the PAS visual scale is not an appropriate marker to be used in the diagnosis of late-onset Alzheimer‘s disease in mild stages.

Název v anglickém jazyce

Magnetic resonance imaging showing parietal atrophy of the brain in lateonset Alzheimer’s disease

Popis výsledku anglicky

Aim: Our intention was to assess whether a scoring of parietal atrophy on MRI of the brain using a simple visual assessment named PAS (Parietal Atrophy Score) could be used in the diagnosis of late-onset Alzheimer‘s disease. Patients and methods: The structure of the parietal lobes was evaluated by our visual scale named PAS, which is based on semiquantitative scoring of atrophy of three structures in the parietal region: sulcus cingularis posterior, precuneus and parietal gyri. Parietal atrophy was assessed in 24 patients with late-onset Alzheimer‘s disease in the stage of mild dementia (Mini-Mental State Examination; MMSE 21 ± 3 points) and 26 age-matched individuals with normal scores on the MMSE (29 ± 1 point). Results: We did not find any statistically significant difference in the size of any structure of the right and left parietal lobe according to the PAS visual scale between control individuals and patients with Alzheimer‘s disease (p &gt; 0.05 in all cases). Conclusion: During late-onset Alzheimer‘s disease there is no significant reduction of parietal cortex until the stage of mild dementia compared to normal aging. Parietal atrophy evaluated according to the PAS visual scale is not an appropriate marker to be used in the diagnosis of late-onset Alzheimer‘s disease in mild stages.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Česká a slovenská neurologie a neurochirurgie

ISSN

1802-4041

e-ISSN

—

Svazek periodika

82

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

91-95

Kód UT WoS článku

000458015800012

EID výsledku v databázi Scopus

2-s2.0-85066997026