Nonlinear Measure of EEG Complexity in the Eker Rat Model of Autism Disorder - a Pilot Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F20%3A43920282" target="_blank" >RIV/00023752:_____/20:43920282 - isvavai.cz</a>

Výsledek na webu

<a href="https://dl.acm.org/doi/10.1145/3409915.3409927" target="_blank" >https://dl.acm.org/doi/10.1145/3409915.3409927</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Nonlinear Measure of EEG Complexity in the Eker Rat Model of Autism Disorder - a Pilot Study

Popis výsledku v původním jazyce

Tuberous Sclerosis Complex (TSC) is a severe pathological condition often accompanied by Autism Spectrum Disorder (ASD) and epilepsy. Recently, conclusions resulting from exploration of animal models suggested inhibition of mTOR to be a potential effective treatment. The EEG activity in Tsc2+/- (Eker) rat model has never been explored before. In this pilot study, we performed nonlinear EEG analysis to characterize its significant alterations resulting from treatment based on mTORi (inhibition of mammalian target of rapamycin), as well as from induction of developmental status epilepticus (DSE). Our results based of approximate entropy calculations confirmed that Everolimu (mTOR inhibitor) has a different influence on the regularity of EEG oscillations in wild-type and Tsc2+/- individuals. Moreover, we did not observe any alteration of EEG pattern complexity in adult rats with a history of DSE, and conclude that genotype (Tsc2+/-) and DSE state are probably influenced by different mechanisms of mTORi, with potential for clinical practice.

Název v anglickém jazyce

Nonlinear Measure of EEG Complexity in the Eker Rat Model of Autism Disorder - a Pilot Study

Popis výsledku anglicky

Tuberous Sclerosis Complex (TSC) is a severe pathological condition often accompanied by Autism Spectrum Disorder (ASD) and epilepsy. Recently, conclusions resulting from exploration of animal models suggested inhibition of mTOR to be a potential effective treatment. The EEG activity in Tsc2+/- (Eker) rat model has never been explored before. In this pilot study, we performed nonlinear EEG analysis to characterize its significant alterations resulting from treatment based on mTORi (inhibition of mammalian target of rapamycin), as well as from induction of developmental status epilepticus (DSE). Our results based of approximate entropy calculations confirmed that Everolimu (mTOR inhibitor) has a different influence on the regularity of EEG oscillations in wild-type and Tsc2+/- individuals. Moreover, we did not observe any alteration of EEG pattern complexity in adult rats with a history of DSE, and conclude that genotype (Tsc2+/-) and DSE state are probably influenced by different mechanisms of mTORi, with potential for clinical practice.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/LO1611" target="_blank" >LO1611: Udržitelnost pro Národní ústav duševního zdraví</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

2nd International Applied Mathematics, Modelling and Simulation Conference (AMMS 2020); June 21-23, 2020

ISBN

978-1-4503-7541-2

ISSN

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e-ISSN

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Počet stran výsledku

5

Strana od-do

49-53

Název nakladatele

ACM International Conference Proceeding

Místo vydání

New York

Místo konání akce

Paris

Datum konání akce

21. 6. 2020

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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