Investigating the phenotypic and genetic associations between personality traits and suicidal behavior across major mental health diagnoses

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F22%3A43920869" target="_blank" >RIV/00023752:_____/22:43920869 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/22:43923000

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s00406-021-01366-5" target="_blank" >https://link.springer.com/article/10.1007/s00406-021-01366-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00406-021-01366-5" target="_blank" >10.1007/s00406-021-01366-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Investigating the phenotypic and genetic associations between personality traits and suicidal behavior across major mental health diagnoses

Popis výsledku v původním jazyce

Personality traits influence risk for suicidal behavior. We examined phenotype- and genotype-level associations between the Big Five personality traits and suicidal ideation and attempt in major depressive, bipolar and schizoaffective disorder, and schizophrenia patients (N = 3012) using fixed- and random-effects inverse variance-weighted meta-analyses. Suicidal ideations were more likely to be reported by patients with higher neuroticism and lower extraversion phenotypic scores, but showed no significant association with polygenic load for these personality traits. Our findings provide new insights into the association between personality and suicidal behavior across mental illnesses and suggest that the genetic component of personality traits is unlikely to have strong causal effects on suicidal behavior.

Název v anglickém jazyce

Investigating the phenotypic and genetic associations between personality traits and suicidal behavior across major mental health diagnoses

Popis výsledku anglicky

Personality traits influence risk for suicidal behavior. We examined phenotype- and genotype-level associations between the Big Five personality traits and suicidal ideation and attempt in major depressive, bipolar and schizoaffective disorder, and schizophrenia patients (N = 3012) using fixed- and random-effects inverse variance-weighted meta-analyses. Suicidal ideations were more likely to be reported by patients with higher neuroticism and lower extraversion phenotypic scores, but showed no significant association with polygenic load for these personality traits. Our findings provide new insights into the association between personality and suicidal behavior across mental illnesses and suggest that the genetic component of personality traits is unlikely to have strong causal effects on suicidal behavior.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30215 - Psychiatry

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Archives of Psychiatry and Clinical Neuroscience

ISSN

0940-1334

e-ISSN

—

Svazek periodika

272

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

1611-1620

Kód UT WoS článku

000753708400001

EID výsledku v databázi Scopus

2-s2.0-85126130537