Attention impairment in motor functional neurological disorders: a neuropsychological study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F22%3A43920906" target="_blank" >RIV/00023752:_____/22:43920906 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/22:10449344 RIV/00216208:11110/22:10449344 RIV/00216208:11210/22:10449344 RIV/00216208:11230/22:10449344

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s00415-022-11211-x" target="_blank" >https://link.springer.com/article/10.1007/s00415-022-11211-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00415-022-11211-x" target="_blank" >10.1007/s00415-022-11211-x</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Attention impairment in motor functional neurological disorders: a neuropsychological study

Popis výsledku v původním jazyce

Objective Our objective was to assess cognitive functioning across multiple cognitive domains using a standardised neuropsychological battery in patients with motor functional neurological disorders (mFND). Methods Thirty patients with clinically established mFND and 30 age-, sex- and education-matched control subjects underwent a thorough neuropsychological assessment evaluating (1) attention including processing speed, (2) executive functions including working memory, (3) short-term memory, (4) speech and language and (5) visuospatial functions. Performance validity tests (PVT) and self-report measures of depression, anxiety and cognitive complaints were included in the assessment. Only patients with valid test performance were included in the analysis. Results Three patients scored below the cut-off scores in PVT. Patients performed significantly worse than controls in the following areas: (1) the attention domain which included a slow processing speed (p = 0.005, Cohen&apos;s d = 0.89), (2) executive functions (p = 0.01, Cohen&apos;s d = 0.88) and (3) speech and language domains (p = 0.025, Cohen&apos;s d = 0.77). Patients with mFND showed greater intra-individual variability in cognitive performance (p = 0.005, Cohen&apos;s d = 0.94). Cognitive impairments were independent of depressive symptoms, which were higher in mFND patients. Conclusion This study revealed both subjective and objective cognitive impairment in patients with mFND. The neuropsychological profile in mFND was characterised primarily by attentional impairment including a slow processing speed and a high intra-individual variability in cognitive performance. Cognitive impairment was associated with a valid test performance, highlighting that the deficits observed were not likely to be explained by a lack of effort in the patient group. Attention is considered to play a key role in mFND pathophysiology, and the results suggest that such impairments are objectively measurable.

Název v anglickém jazyce

Attention impairment in motor functional neurological disorders: a neuropsychological study

Popis výsledku anglicky

Objective Our objective was to assess cognitive functioning across multiple cognitive domains using a standardised neuropsychological battery in patients with motor functional neurological disorders (mFND). Methods Thirty patients with clinically established mFND and 30 age-, sex- and education-matched control subjects underwent a thorough neuropsychological assessment evaluating (1) attention including processing speed, (2) executive functions including working memory, (3) short-term memory, (4) speech and language and (5) visuospatial functions. Performance validity tests (PVT) and self-report measures of depression, anxiety and cognitive complaints were included in the assessment. Only patients with valid test performance were included in the analysis. Results Three patients scored below the cut-off scores in PVT. Patients performed significantly worse than controls in the following areas: (1) the attention domain which included a slow processing speed (p = 0.005, Cohen&apos;s d = 0.89), (2) executive functions (p = 0.01, Cohen&apos;s d = 0.88) and (3) speech and language domains (p = 0.025, Cohen&apos;s d = 0.77). Patients with mFND showed greater intra-individual variability in cognitive performance (p = 0.005, Cohen&apos;s d = 0.94). Cognitive impairments were independent of depressive symptoms, which were higher in mFND patients. Conclusion This study revealed both subjective and objective cognitive impairment in patients with mFND. The neuropsychological profile in mFND was characterised primarily by attentional impairment including a slow processing speed and a high intra-individual variability in cognitive performance. Cognitive impairment was associated with a valid test performance, highlighting that the deficits observed were not likely to be explained by a lack of effort in the patient group. Attention is considered to play a key role in mFND pathophysiology, and the results suggest that such impairments are objectively measurable.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

<a href="/cs/project/NV16-29651A" target="_blank" >NV16-29651A: Diagnostické neurofyziologické a laboratorní markery a patofyziologické mechanismy funkčních poruch hybnosti</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Neurology

ISSN

0340-5354

e-ISSN

1432-1459

Svazek periodika

269

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

5981-5990

Kód UT WoS článku

000826269600001

EID výsledku v databázi Scopus

2-s2.0-85134478587