The effect of low-frequency rTMS on auditory hallucinations, EEG source localization and functional connectivity in schizophrenia
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F23%3A43920991" target="_blank" >RIV/00023752:_____/23:43920991 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11120/23:43924450
Výsledek na webu
<a href="https://linkinghub.elsevier.com/retrieve/pii/S0304394022005389" target="_blank" >https://linkinghub.elsevier.com/retrieve/pii/S0304394022005389</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.neulet.2022.136977" target="_blank" >10.1016/j.neulet.2022.136977</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The effect of low-frequency rTMS on auditory hallucinations, EEG source localization and functional connectivity in schizophrenia
Popis výsledku v původním jazyce
Background: Low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) diminishes auditory hallu-cinations (AHs). The aims of our study were a) to assess the efficacy of LF-rTMS in a randomized, sham-controlleddouble-blind alignment, b) to identify the electrophysiological changes accompanying the LF-rTMS, and c) toidentify the influence of LF-rTMS on brain functional connectivity (FC).Methods: Nineteen schizophrenia patients with antipsychotic-resistant AHs were randomized to either active (n= 10) or sham (n = 9) LF-rTMS administered over the left temporo-parietal region for ten days. The clinical effectwas assessed by the Auditory Hallucination Rating Scale (AHRS). The localization of the differences in electricalactivity was identified by standardized low resolution brain electromagnetic tomography (sLORETA) and FC wasmeasured by lagged phase synchronization.Results: AHRS scores were significantly improved for patients receiving active rTMS compared to the sham(median reduction: 40 % vs 12 %; p = 0.01). sLORETA revealed a decrease of alpha-2, beta-1,-2 bands in the lefthemisphere in the active group. Active rTMS led to a decrease of the lagged phase connectivity in beta bandsoriginating in areas close to the site of stimulation, and to a prevailing increase of alpha-2 FC. No significantdifferences in current density or FC were observed in the sham group.Limitations: Limitations to our study included the small group sizes, and the disability of LORETA to assesssubcortical neuronal activity.Conclusions: LF-rTMS attenuated AHs and induced a decrease of higher frequency bands on the left hemisphere. The FC changes support the assumption that LF-rTMS is linked to the modulation of cortico-cortical coupling.
Název v anglickém jazyce
The effect of low-frequency rTMS on auditory hallucinations, EEG source localization and functional connectivity in schizophrenia
Popis výsledku anglicky
Background: Low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) diminishes auditory hallu-cinations (AHs). The aims of our study were a) to assess the efficacy of LF-rTMS in a randomized, sham-controlleddouble-blind alignment, b) to identify the electrophysiological changes accompanying the LF-rTMS, and c) toidentify the influence of LF-rTMS on brain functional connectivity (FC).Methods: Nineteen schizophrenia patients with antipsychotic-resistant AHs were randomized to either active (n= 10) or sham (n = 9) LF-rTMS administered over the left temporo-parietal region for ten days. The clinical effectwas assessed by the Auditory Hallucination Rating Scale (AHRS). The localization of the differences in electricalactivity was identified by standardized low resolution brain electromagnetic tomography (sLORETA) and FC wasmeasured by lagged phase synchronization.Results: AHRS scores were significantly improved for patients receiving active rTMS compared to the sham(median reduction: 40 % vs 12 %; p = 0.01). sLORETA revealed a decrease of alpha-2, beta-1,-2 bands in the lefthemisphere in the active group. Active rTMS led to a decrease of the lagged phase connectivity in beta bandsoriginating in areas close to the site of stimulation, and to a prevailing increase of alpha-2 FC. No significantdifferences in current density or FC were observed in the sham group.Limitations: Limitations to our study included the small group sizes, and the disability of LORETA to assesssubcortical neuronal activity.Conclusions: LF-rTMS attenuated AHs and induced a decrease of higher frequency bands on the left hemisphere. The FC changes support the assumption that LF-rTMS is linked to the modulation of cortico-cortical coupling.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30215 - Psychiatry
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Neuroscience Letters
ISSN
0304-3940
e-ISSN
1872-7972
Svazek periodika
794
Číslo periodika v rámci svazku
"Article number 136977"
Stát vydavatele periodika
IE - Irsko
Počet stran výsledku
7
Strana od-do
1-7
Kód UT WoS článku
000904998700005
EID výsledku v databázi Scopus
2-s2.0-85143736457