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The effect of low-frequency rTMS on auditory hallucinations, EEG source localization and functional connectivity in schizophrenia

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F23%3A43920991" target="_blank" >RIV/00023752:_____/23:43920991 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00216208:11120/23:43924450

  • Výsledek na webu

    <a href="https://linkinghub.elsevier.com/retrieve/pii/S0304394022005389" target="_blank" >https://linkinghub.elsevier.com/retrieve/pii/S0304394022005389</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.neulet.2022.136977" target="_blank" >10.1016/j.neulet.2022.136977</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    The effect of low-frequency rTMS on auditory hallucinations, EEG source localization and functional connectivity in schizophrenia

  • Popis výsledku v původním jazyce

    Background: Low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) diminishes auditory hallu-cinations (AHs). The aims of our study were a) to assess the efficacy of LF-rTMS in a randomized, sham-controlleddouble-blind alignment, b) to identify the electrophysiological changes accompanying the LF-rTMS, and c) toidentify the influence of LF-rTMS on brain functional connectivity (FC).Methods: Nineteen schizophrenia patients with antipsychotic-resistant AHs were randomized to either active (n= 10) or sham (n = 9) LF-rTMS administered over the left temporo-parietal region for ten days. The clinical effectwas assessed by the Auditory Hallucination Rating Scale (AHRS). The localization of the differences in electricalactivity was identified by standardized low resolution brain electromagnetic tomography (sLORETA) and FC wasmeasured by lagged phase synchronization.Results: AHRS scores were significantly improved for patients receiving active rTMS compared to the sham(median reduction: 40 % vs 12 %; p = 0.01). sLORETA revealed a decrease of alpha-2, beta-1,-2 bands in the lefthemisphere in the active group. Active rTMS led to a decrease of the lagged phase connectivity in beta bandsoriginating in areas close to the site of stimulation, and to a prevailing increase of alpha-2 FC. No significantdifferences in current density or FC were observed in the sham group.Limitations: Limitations to our study included the small group sizes, and the disability of LORETA to assesssubcortical neuronal activity.Conclusions: LF-rTMS attenuated AHs and induced a decrease of higher frequency bands on the left hemisphere. The FC changes support the assumption that LF-rTMS is linked to the modulation of cortico-cortical coupling.

  • Název v anglickém jazyce

    The effect of low-frequency rTMS on auditory hallucinations, EEG source localization and functional connectivity in schizophrenia

  • Popis výsledku anglicky

    Background: Low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) diminishes auditory hallu-cinations (AHs). The aims of our study were a) to assess the efficacy of LF-rTMS in a randomized, sham-controlleddouble-blind alignment, b) to identify the electrophysiological changes accompanying the LF-rTMS, and c) toidentify the influence of LF-rTMS on brain functional connectivity (FC).Methods: Nineteen schizophrenia patients with antipsychotic-resistant AHs were randomized to either active (n= 10) or sham (n = 9) LF-rTMS administered over the left temporo-parietal region for ten days. The clinical effectwas assessed by the Auditory Hallucination Rating Scale (AHRS). The localization of the differences in electricalactivity was identified by standardized low resolution brain electromagnetic tomography (sLORETA) and FC wasmeasured by lagged phase synchronization.Results: AHRS scores were significantly improved for patients receiving active rTMS compared to the sham(median reduction: 40 % vs 12 %; p = 0.01). sLORETA revealed a decrease of alpha-2, beta-1,-2 bands in the lefthemisphere in the active group. Active rTMS led to a decrease of the lagged phase connectivity in beta bandsoriginating in areas close to the site of stimulation, and to a prevailing increase of alpha-2 FC. No significantdifferences in current density or FC were observed in the sham group.Limitations: Limitations to our study included the small group sizes, and the disability of LORETA to assesssubcortical neuronal activity.Conclusions: LF-rTMS attenuated AHs and induced a decrease of higher frequency bands on the left hemisphere. The FC changes support the assumption that LF-rTMS is linked to the modulation of cortico-cortical coupling.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30215 - Psychiatry

Návaznosti výsledku

  • Projekt

    Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2023

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Neuroscience Letters

  • ISSN

    0304-3940

  • e-ISSN

    1872-7972

  • Svazek periodika

    794

  • Číslo periodika v rámci svazku

    "Article number 136977"

  • Stát vydavatele periodika

    IE - Irsko

  • Počet stran výsledku

    7

  • Strana od-do

    1-7

  • Kód UT WoS článku

    000904998700005

  • EID výsledku v databázi Scopus

    2-s2.0-85143736457