Molecular Biomarkers of Neuronal Injury in Epilepsy Shared with Neurodegenerative Diseases
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F23%3A43921063" target="_blank" >RIV/00023752:_____/23:43921063 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216224:14740/23:00133507 RIV/00216208:11120/23:43925239 RIV/00159816:_____/23:00078775
Výsledek na webu
<a href="https://link.springer.com/article/10.1007/s13311-023-01355-7" target="_blank" >https://link.springer.com/article/10.1007/s13311-023-01355-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13311-023-01355-7" target="_blank" >10.1007/s13311-023-01355-7</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Molecular Biomarkers of Neuronal Injury in Epilepsy Shared with Neurodegenerative Diseases
Popis výsledku v původním jazyce
In neurodegenerative diseases, changes in neuronal proteins in the cerebrospinal fluid and blood are viewed as potential biomarkers of the primary pathology in the central nervous system (CNS). Recent reports suggest, however, that level of neuronal proteins in fluids also alters in several types of epilepsy in various age groups, including children. With increasing evidence supporting clinical and sub-clinical seizures in Alzheimer's disease, Lewy body dementia, Parkinson's disease, and in other less common neurodegenerative conditions, these findings call into question the specificity of neuronal protein response to neurodegenerative process and urge analysis of the effects of concomitant epilepsy and other comorbidities. In this article, we revisit the evidence for alterations in neuronal proteins in the blood and cerebrospinal fluid associated with epilepsy with and without neurodegenerative diseases. We discuss shared and distinctive characteristics of changes in neuronal markers, review their neurobiological mechanisms, and consider the emerging opportunities and challenges for their future research and diagnostic use.
Název v anglickém jazyce
Molecular Biomarkers of Neuronal Injury in Epilepsy Shared with Neurodegenerative Diseases
Popis výsledku anglicky
In neurodegenerative diseases, changes in neuronal proteins in the cerebrospinal fluid and blood are viewed as potential biomarkers of the primary pathology in the central nervous system (CNS). Recent reports suggest, however, that level of neuronal proteins in fluids also alters in several types of epilepsy in various age groups, including children. With increasing evidence supporting clinical and sub-clinical seizures in Alzheimer's disease, Lewy body dementia, Parkinson's disease, and in other less common neurodegenerative conditions, these findings call into question the specificity of neuronal protein response to neurodegenerative process and urge analysis of the effects of concomitant epilepsy and other comorbidities. In this article, we revisit the evidence for alterations in neuronal proteins in the blood and cerebrospinal fluid associated with epilepsy with and without neurodegenerative diseases. We discuss shared and distinctive characteristics of changes in neuronal markers, review their neurobiological mechanisms, and consider the emerging opportunities and challenges for their future research and diagnostic use.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30103 - Neurosciences (including psychophysiology)
Návaznosti výsledku
Projekt
—
Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Neurotherapeutics
ISSN
1933-7213
e-ISSN
1878-7479
Svazek periodika
20
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
12
Strana od-do
767-778
Kód UT WoS článku
000945760600001
EID výsledku v databázi Scopus
2-s2.0-85149971500