Cellular and molecular mechanisms of action of ovarian steroid hormones. I: Regulation of central nervous system function

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F23%3A43921388" target="_blank" >RIV/00023752:_____/23:43921388 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11240/24:10492124

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0149763424004068?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0149763424004068?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neubiorev.2024.105937" target="_blank" >10.1016/j.neubiorev.2024.105937</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cellular and molecular mechanisms of action of ovarian steroid hormones. I: Regulation of central nervous system function

Popis výsledku v původním jazyce

The conventional way steroid hormones work through receptors inside cells is widely acknowledged. There are unanswered questions about what happens to the hormone in the end and why there isn&apos;t always a strong connection between how much tissue takes up and its biological effects through receptor binding. Steroid hormones can also have non-traditional effects that happen quickly but don&apos;t involve entering the cell. Several possible mechanisms for these non-traditional actions include (a) changes in membrane fluidity, (b) steroid hormones acting on receptors on the outer surface of cells, (c) steroid hormones regulating GABAA receptors on cell membranes, and (d) activation of steroid receptors by factors like EGF, IGF-1, and dopamine. Data also suggests that steroid hormones may be inserted into DNA through receptors, acting as transcription factors. These proposed new mechanisms of action should not be seen as challenging the conventional mechanism. Instead, they contribute to a more comprehensive understanding of how hormones work, allowing for rapid, short-term, and prolonged effects to meet the body&apos;s physiological needs.

Název v anglickém jazyce

Cellular and molecular mechanisms of action of ovarian steroid hormones. I: Regulation of central nervous system function

Popis výsledku anglicky

The conventional way steroid hormones work through receptors inside cells is widely acknowledged. There are unanswered questions about what happens to the hormone in the end and why there isn&apos;t always a strong connection between how much tissue takes up and its biological effects through receptor binding. Steroid hormones can also have non-traditional effects that happen quickly but don&apos;t involve entering the cell. Several possible mechanisms for these non-traditional actions include (a) changes in membrane fluidity, (b) steroid hormones acting on receptors on the outer surface of cells, (c) steroid hormones regulating GABAA receptors on cell membranes, and (d) activation of steroid receptors by factors like EGF, IGF-1, and dopamine. Data also suggests that steroid hormones may be inserted into DNA through receptors, acting as transcription factors. These proposed new mechanisms of action should not be seen as challenging the conventional mechanism. Instead, they contribute to a more comprehensive understanding of how hormones work, allowing for rapid, short-term, and prolonged effects to meet the body&apos;s physiological needs.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroscience and Biobehavioral Reviews

ISSN

0149-7634

e-ISSN

1873-7528

Svazek periodika

167

Číslo periodika v rámci svazku

"Article number :105937"

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

21

Strana od-do

1-21

Kód UT WoS článku

001359293600001

EID výsledku v databázi Scopus

2-s2.0-85209146458