Influence of environmental enrichment on sexual behavior and the process of learning and memory in a rat model of autism with valproic acid

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F24%3A43921190" target="_blank" >RIV/00023752:_____/24:43921190 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11240/24:10475936

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0006899323005097" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0006899323005097</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.brainres.2023.148738" target="_blank" >10.1016/j.brainres.2023.148738</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Influence of environmental enrichment on sexual behavior and the process of learning and memory in a rat model of autism with valproic acid

Popis výsledku v původním jazyce

Autism spectrum disorder (ASD) is a psychiatric disorder with severe behavioral consequences and no specifictherapy. Its etiology is multifactorial, as it is caused by a complex interaction of genetic and environmentalfactors. In rats, prenatal exposure to the antiepileptic drug valproic acid (VPA) has been associated with anincreased risk of autistic-like behaviors in offspring, including social behavior deficits, increased repetitive behaviors, and cognitive impairments. In addition, VPA-treated rats have shown altered sociosexual behaviors.However, the mechanisms underlying these alterations in reproductive processes in VPA-treated rats are not fullyunderstood. Interestingly some abnormal behaviors in VPA autism models are improved by an enriched environment (EE). In the present study, we examined the effects of EE on memory performance and sexual behaviorin male rats. We found that on postnatal day 90, EE reduced the time it took for both control and VPA-treatedgroups to find a hidden platform in the Morris water maze. On PND 100, prenatal exposure to VPA reduced totalexploring time in object recognition tests. On PND 110, EE reduced mount and intromission latency andincreased ejaculatory frequency in VPA-treated male rats. These results suggest that environmental stimulisignificantly influence the onset of sexual behavior in VPA-treated male rats and that EE may be a potential toolfor improving a variety of behavioral deficiencies in rodent models of autism.

Název v anglickém jazyce

Influence of environmental enrichment on sexual behavior and the process of learning and memory in a rat model of autism with valproic acid

Popis výsledku anglicky

Autism spectrum disorder (ASD) is a psychiatric disorder with severe behavioral consequences and no specifictherapy. Its etiology is multifactorial, as it is caused by a complex interaction of genetic and environmentalfactors. In rats, prenatal exposure to the antiepileptic drug valproic acid (VPA) has been associated with anincreased risk of autistic-like behaviors in offspring, including social behavior deficits, increased repetitive behaviors, and cognitive impairments. In addition, VPA-treated rats have shown altered sociosexual behaviors.However, the mechanisms underlying these alterations in reproductive processes in VPA-treated rats are not fullyunderstood. Interestingly some abnormal behaviors in VPA autism models are improved by an enriched environment (EE). In the present study, we examined the effects of EE on memory performance and sexual behaviorin male rats. We found that on postnatal day 90, EE reduced the time it took for both control and VPA-treatedgroups to find a hidden platform in the Morris water maze. On PND 100, prenatal exposure to VPA reduced totalexploring time in object recognition tests. On PND 110, EE reduced mount and intromission latency andincreased ejaculatory frequency in VPA-treated male rats. These results suggest that environmental stimulisignificantly influence the onset of sexual behavior in VPA-treated male rats and that EE may be a potential toolfor improving a variety of behavioral deficiencies in rodent models of autism.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30105 - Physiology (including cytology)

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Brain Research

ISSN

0006-8993

e-ISSN

1872-6240

Svazek periodika

1827

Číslo periodika v rámci svazku

"Article number 148738"

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

1-8

Kód UT WoS článku

001153773100001

EID výsledku v databázi Scopus

2-s2.0-85181829082