Cerebellar impairments in genetic models of autism spectrum disorders: A neurobiological perspective

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F24%3A43921387" target="_blank" >RIV/00023752:_____/24:43921387 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/24:43927744

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0301008224001217?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0301008224001217?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pneurobio.2024.102685" target="_blank" >10.1016/j.pneurobio.2024.102685</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cerebellar impairments in genetic models of autism spectrum disorders: A neurobiological perspective

Popis výsledku v původním jazyce

Functional and molecular alterations in the cerebellum are among the most widely recognised associates of autism spectrum disorders (ASD). As a critical computational hub of the brain, the cerebellum controls and coordinates a range of motor, affective and cognitive processes. Despite well-described circuits and integrative mechanisms, specific changes that underlie cerebellar impairments in ASD remain elusive. Studies in experimental animals have been critical in uncovering molecular pathology and neuro-behavioural correlates, providing a model for investigating complex disease conditions. Herein, we review commonalities and differences of the most extensively characterised genetic lines of ASD with reference to the cerebellum. We revisit structural, functional, and molecular alterations which may contribute to neurobehavioral phenotypes. The cross-model analysis of this study provides an integrated outlook on the role of cerebellar alterations in pathobiology of ASD that may benefit future translational research and development of therapies.

Název v anglickém jazyce

Cerebellar impairments in genetic models of autism spectrum disorders: A neurobiological perspective

Popis výsledku anglicky

Functional and molecular alterations in the cerebellum are among the most widely recognised associates of autism spectrum disorders (ASD). As a critical computational hub of the brain, the cerebellum controls and coordinates a range of motor, affective and cognitive processes. Despite well-described circuits and integrative mechanisms, specific changes that underlie cerebellar impairments in ASD remain elusive. Studies in experimental animals have been critical in uncovering molecular pathology and neuro-behavioural correlates, providing a model for investigating complex disease conditions. Herein, we review commonalities and differences of the most extensively characterised genetic lines of ASD with reference to the cerebellum. We revisit structural, functional, and molecular alterations which may contribute to neurobehavioral phenotypes. The cross-model analysis of this study provides an integrated outlook on the role of cerebellar alterations in pathobiology of ASD that may benefit future translational research and development of therapies.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Progress in Neurobiology

ISSN

0301-0082

e-ISSN

1873-5118

Svazek periodika

242

Číslo periodika v rámci svazku

"Article Number: 102685"

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

1-14

Kód UT WoS článku

001357124000001

EID výsledku v databázi Scopus

2-s2.0-85208562335