Unveiling stimulus transduction artifacts in auditory steady-state response experiments: Characterization, risks, and mitigation strategies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F25%3A43921457" target="_blank" >RIV/00023752:_____/25:43921457 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21460/25:00379312 RIV/00216208:11120/25:43927782

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1746809424011868?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1746809424011868?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bspc.2024.107128" target="_blank" >10.1016/j.bspc.2024.107128</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Unveiling stimulus transduction artifacts in auditory steady-state response experiments: Characterization, risks, and mitigation strategies

Popis výsledku v původním jazyce

This scientific paper addresses the potential risk of spurious responses in neuroscientific auditory steady-state response (ASSR) experiments attributed to transduction artifacts. The focus is particularly on click train stimuli, given their spectral content in the frequency range of interest (e.g., 40 Hz). Building upon a pilot experiment demonstrating the existence of the artifact in a phantom head, this study focuses on the characterization of stimulus artifacts in extended measurements with phantoms and the evaluation of associated risks in experiments involving human subjects, where 15 subjects were stimulated by headphones and speakers, which served as a control condition. The investigation is divided into two parts: the first part scrutinizes stimulus artifact properties crucial for mitigation, while the second part assesses risks in ASSR experiments with human subjects based on the characterized artifact. The discussion covers stimulus characterization, experimental setups with phantoms, and experiments with human subjects, exploring potential sources of the artifact, its spatial properties, and the influence of re-referencing, which can suppress a less prominent artifact while significantly increasing the prominent and focused artifact. The results reveal the role of headphone cables as a source of stimulus artifacts, along with the surprising impact of headphone transducers. The study emphasizes the need for careful experimental design. We proposes specific data analyses assessing cross- frequency correlation maps and the topographic structure of the brain response at higher harmonic frequencies of the fundamental 40 Hz component. These steps, if applied appropriately, will prevent misinterpretation of stimulus artifacts as genuine brain responses in ASSR experiments.

Název v anglickém jazyce

Unveiling stimulus transduction artifacts in auditory steady-state response experiments: Characterization, risks, and mitigation strategies

Popis výsledku anglicky

This scientific paper addresses the potential risk of spurious responses in neuroscientific auditory steady-state response (ASSR) experiments attributed to transduction artifacts. The focus is particularly on click train stimuli, given their spectral content in the frequency range of interest (e.g., 40 Hz). Building upon a pilot experiment demonstrating the existence of the artifact in a phantom head, this study focuses on the characterization of stimulus artifacts in extended measurements with phantoms and the evaluation of associated risks in experiments involving human subjects, where 15 subjects were stimulated by headphones and speakers, which served as a control condition. The investigation is divided into two parts: the first part scrutinizes stimulus artifact properties crucial for mitigation, while the second part assesses risks in ASSR experiments with human subjects based on the characterized artifact. The discussion covers stimulus characterization, experimental setups with phantoms, and experiments with human subjects, exploring potential sources of the artifact, its spatial properties, and the influence of re-referencing, which can suppress a less prominent artifact while significantly increasing the prominent and focused artifact. The results reveal the role of headphone cables as a source of stimulus artifacts, along with the surprising impact of headphone transducers. The study emphasizes the need for careful experimental design. We proposes specific data analyses assessing cross- frequency correlation maps and the topographic structure of the brain response at higher harmonic frequencies of the fundamental 40 Hz component. These steps, if applied appropriately, will prevent misinterpretation of stimulus artifacts as genuine brain responses in ASSR experiments.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Signal Processing and Control

ISSN

1746-8094

e-ISSN

1746-8108

Svazek periodika

101

Číslo periodika v rámci svazku

"Article Number 107128"

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

1-14

Kód UT WoS článku

001396199500001

EID výsledku v databázi Scopus

2-s2.0-85210130199