Disruptive effects of d-amphetamine on conditioned sexual inhibition in the male rat

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F25%3A43921528" target="_blank" >RIV/00023752:_____/25:43921528 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11240/25:10512782

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s00213-025-06786-y" target="_blank" >https://link.springer.com/article/10.1007/s00213-025-06786-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00213-025-06786-y" target="_blank" >10.1007/s00213-025-06786-y</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Disruptive effects of d-amphetamine on conditioned sexual inhibition in the male rat

Popis výsledku v původním jazyce

RationaleMale rats trained to associate a neutral odor (almond) with nonreceptive females during their initial sexual experiences develop a conditioned sexual inhibition (CSI) toward the female bearing the olfactory cue when given a choice in a final copulatory preference test between two receptive females (one unscented and one scented) in an open field. We have previously shown that this CSI can be abolished by acute alcohol before the final copulatory preference test.ObjectiveTo examine whether acute treatment with d-amphetamine could also disrupt CSI.MethodsMale rats received 20 alternating conditioning sessions with an unscented receptive female or an almond-scented non-receptive female. Forty minutes prior to the copulatory preference test with two receptive females, one unscented and the other scented (almond extract), males were injected with saline or one of three doses of d-amphetamine (d- 0.5, 1.0, or 2.0 mg/kg). After two reconditioning trials, males were injected with d-amp or saline and exposed to the olfactory cue alone for 1 h. Brains were fixed and processed for immunohistochemical analysis of Fos protein as a marker of neuronal activation. Fos expression was assessed in several brain regions involved in male sexual behavior.ResultsSaline-treated males displayed inhibition of copulatory behavior directed toward the scented female. In contrast, and regardless of the dose, males treated with d-amp prior to the final test copulated with both scented and unscented females, indicating that d-amp disrupted the CSI. Exposure to d-amphetamine and the odor alone induced a differential pattern of Fos expression in several brain areas involved in the expression and/or the regulation of male sexual behavior.ConclusionsAs observed previously with alcohol, a low dose of d-amphetamine disrupted the display of a CSI by acting on brain regions mediating sexual behavior.

Název v anglickém jazyce

Disruptive effects of d-amphetamine on conditioned sexual inhibition in the male rat

Popis výsledku anglicky

RationaleMale rats trained to associate a neutral odor (almond) with nonreceptive females during their initial sexual experiences develop a conditioned sexual inhibition (CSI) toward the female bearing the olfactory cue when given a choice in a final copulatory preference test between two receptive females (one unscented and one scented) in an open field. We have previously shown that this CSI can be abolished by acute alcohol before the final copulatory preference test.ObjectiveTo examine whether acute treatment with d-amphetamine could also disrupt CSI.MethodsMale rats received 20 alternating conditioning sessions with an unscented receptive female or an almond-scented non-receptive female. Forty minutes prior to the copulatory preference test with two receptive females, one unscented and the other scented (almond extract), males were injected with saline or one of three doses of d-amphetamine (d- 0.5, 1.0, or 2.0 mg/kg). After two reconditioning trials, males were injected with d-amp or saline and exposed to the olfactory cue alone for 1 h. Brains were fixed and processed for immunohistochemical analysis of Fos protein as a marker of neuronal activation. Fos expression was assessed in several brain regions involved in male sexual behavior.ResultsSaline-treated males displayed inhibition of copulatory behavior directed toward the scented female. In contrast, and regardless of the dose, males treated with d-amp prior to the final test copulated with both scented and unscented females, indicating that d-amp disrupted the CSI. Exposure to d-amphetamine and the odor alone induced a differential pattern of Fos expression in several brain areas involved in the expression and/or the regulation of male sexual behavior.ConclusionsAs observed previously with alcohol, a low dose of d-amphetamine disrupted the display of a CSI by acting on brain regions mediating sexual behavior.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Psychopharmacology

ISSN

0033-3158

e-ISSN

1432-2072

Svazek periodika

242

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

2097-2110

Kód UT WoS článku

001466980800001

EID výsledku v databázi Scopus

2-s2.0-105003234679