A Comprehensive Review of Selenium as a Key Regulator in Thyroid Health

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F25%3A43921529" target="_blank" >RIV/00023752:_____/25:43921529 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/25:10515726

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s12011-025-04653-7" target="_blank" >https://link.springer.com/article/10.1007/s12011-025-04653-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12011-025-04653-7" target="_blank" >10.1007/s12011-025-04653-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A Comprehensive Review of Selenium as a Key Regulator in Thyroid Health

Popis výsledku v původním jazyce

Selenium (Se) is an essential trace element crucial for thyroid function, participating in the production and metabolism of thyroid hormones and the immune system. It engages in synthesizing selenoproteins, which are essential for antioxidant defense and regulating thyroid hormone levels. It is crucial to convert thyroxine (T4) into the active thyroid hormone triiodothyronine (T3) via deiodinase activity and safeguard thyroid cells from oxidative damage. Therefore, thyroid dysfunction, including abnormalities in thyroid hormone synthesis and the emergence of autoimmune thyroid conditions such as Graves’ disease and Hashimoto’s thyroiditis, has been linked to Se deficiency. When evaluating the benefits of Se supplementation, it is crucial to recognize that excessive mineral intake may be detrimental and result in adverse consequences, including gastrointestinal disturbances and neurological problems. The effectiveness of Se-based therapies is influenced by individual characteristics, including hereditary anomalies in thyroid function and Se metabolism. Further research should be performed on personalized Se supplementation approaches using genetics and nanotechnology to optimize the bioavailability and efficacy of the supplements. This study aims to thoroughly examine Se’s role in thyroid health and how its therapeutic use in thyroid-related diseases may be optimized via appropriate dosing.

Název v anglickém jazyce

A Comprehensive Review of Selenium as a Key Regulator in Thyroid Health

Popis výsledku anglicky

Selenium (Se) is an essential trace element crucial for thyroid function, participating in the production and metabolism of thyroid hormones and the immune system. It engages in synthesizing selenoproteins, which are essential for antioxidant defense and regulating thyroid hormone levels. It is crucial to convert thyroxine (T4) into the active thyroid hormone triiodothyronine (T3) via deiodinase activity and safeguard thyroid cells from oxidative damage. Therefore, thyroid dysfunction, including abnormalities in thyroid hormone synthesis and the emergence of autoimmune thyroid conditions such as Graves’ disease and Hashimoto’s thyroiditis, has been linked to Se deficiency. When evaluating the benefits of Se supplementation, it is crucial to recognize that excessive mineral intake may be detrimental and result in adverse consequences, including gastrointestinal disturbances and neurological problems. The effectiveness of Se-based therapies is influenced by individual characteristics, including hereditary anomalies in thyroid function and Se metabolism. Further research should be performed on personalized Se supplementation approaches using genetics and nanotechnology to optimize the bioavailability and efficacy of the supplements. This study aims to thoroughly examine Se’s role in thyroid health and how its therapeutic use in thyroid-related diseases may be optimized via appropriate dosing.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biological Trace Element Research

ISSN

0163-4984

e-ISSN

1559-0720

Svazek periodika

203

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

15

Strana od-do

6466-6480

Kód UT WoS článku

001494234600001

EID výsledku v databázi Scopus

2-s2.0-105004905803