Mental health in patients with rheumatoid arthritis and axial spondyloarthritis: a cross-sectional, case–control tertiary centre study from Czechia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F25%3A43921628" target="_blank" >RIV/00023752:_____/25:43921628 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/25:10506912 RIV/00216208:11120/25:43929233 RIV/00023728:_____/25:N0000050

Výsledek na webu

<a href="https://bmjopen.bmj.com/content/15/12/e103686" target="_blank" >https://bmjopen.bmj.com/content/15/12/e103686</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/bmjopen-2025-103686" target="_blank" >10.1136/bmjopen-2025-103686</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mental health in patients with rheumatoid arthritis and axial spondyloarthritis: a cross-sectional, case–control tertiary centre study from Czechia

Popis výsledku v původním jazyce

Objectives To evaluate the mental health burden in rheumatoid arthritis (RA) and axial spondyloarthritis (axSpA) using diagnostic and self-reported tools and to examine its associations with current disease activity, patient-reported outcomes and barriers to appropriate care. Design Single-centre, cross-sectional, case-control study. Setting Rheumatology centre of a tertiary care hospital, serving as a referral clinic with outpatient and inpatient care in Czech Republic. Participants 233 patients with rheumatic diseases (113 RA, 120 axSpA) and 170 healthy controls (HC). Outcome measures Mental disorders (MD) were assessed through a structured psychiatric interview using the International Neuropsychiatric Interview (Mini International Neuropsychiatric Interview) administered by a trained professional and by self-reported questionnaires including the Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI). Disease activity was evaluated with the Disease Activity Score-28 with C-reactive protein (DAS28-CRP) for RA and the Ankylosing Spondylitis Disease Activity Score with CRP (ASDAS-CRP) for axSpA, alongside patient-reported outcomes (PROs).Results At least one MD was present in 24.8% of RA, 31.7% of axSpA and 7.0% of HC (p&lt;0.001), driven mainly by major depression, dysthymia and suicidal ideation. Thresholds for depression and anxiety were significantly more frequent in RA and axSpA than HC (BDI-II: 18.6% vs 4.0% and 17.5% vs 1.7%; BAI: 38.9% vs 13.9% and 26.7% vs 11.0%; all p&lt;0.001). Patients with MD had higher disease activity (RA: DAS28-CRP 3.12 vs 2.68, p&lt;0.05; axSpA: ASDAS-CRP 2.39 vs 1.63, p&lt;0.001). The presence of MD was associated with an increase of 0.40 in DAS28-CRP and 0.24 in ASDAS-CRP, although a 10-point increase in BDI-II was required for a similar association. Most patients with MD (75.0% RA, 89.6% axSpA) declined psychiatric counselling despite poorer concurrent outcomes in disease activity and PROs. Conclusions Mental disorders in RA and axSpA are closely associated with higher disease activity and unfavourable PROs, while access to and acceptance of psychiatric care remain markedly insufficient. Systematic integration of mental health assessment and management into rheumatology practice is strongly warranted.

Název v anglickém jazyce

Mental health in patients with rheumatoid arthritis and axial spondyloarthritis: a cross-sectional, case–control tertiary centre study from Czechia

Popis výsledku anglicky

Objectives To evaluate the mental health burden in rheumatoid arthritis (RA) and axial spondyloarthritis (axSpA) using diagnostic and self-reported tools and to examine its associations with current disease activity, patient-reported outcomes and barriers to appropriate care. Design Single-centre, cross-sectional, case-control study. Setting Rheumatology centre of a tertiary care hospital, serving as a referral clinic with outpatient and inpatient care in Czech Republic. Participants 233 patients with rheumatic diseases (113 RA, 120 axSpA) and 170 healthy controls (HC). Outcome measures Mental disorders (MD) were assessed through a structured psychiatric interview using the International Neuropsychiatric Interview (Mini International Neuropsychiatric Interview) administered by a trained professional and by self-reported questionnaires including the Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI). Disease activity was evaluated with the Disease Activity Score-28 with C-reactive protein (DAS28-CRP) for RA and the Ankylosing Spondylitis Disease Activity Score with CRP (ASDAS-CRP) for axSpA, alongside patient-reported outcomes (PROs).Results At least one MD was present in 24.8% of RA, 31.7% of axSpA and 7.0% of HC (p&lt;0.001), driven mainly by major depression, dysthymia and suicidal ideation. Thresholds for depression and anxiety were significantly more frequent in RA and axSpA than HC (BDI-II: 18.6% vs 4.0% and 17.5% vs 1.7%; BAI: 38.9% vs 13.9% and 26.7% vs 11.0%; all p&lt;0.001). Patients with MD had higher disease activity (RA: DAS28-CRP 3.12 vs 2.68, p&lt;0.05; axSpA: ASDAS-CRP 2.39 vs 1.63, p&lt;0.001). The presence of MD was associated with an increase of 0.40 in DAS28-CRP and 0.24 in ASDAS-CRP, although a 10-point increase in BDI-II was required for a similar association. Most patients with MD (75.0% RA, 89.6% axSpA) declined psychiatric counselling despite poorer concurrent outcomes in disease activity and PROs. Conclusions Mental disorders in RA and axSpA are closely associated with higher disease activity and unfavourable PROs, while access to and acceptance of psychiatric care remain markedly insufficient. Systematic integration of mental health assessment and management into rheumatology practice is strongly warranted.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30218 - General and internal medicine

Projekt

<a href="/cs/project/NU21-09-00297" target="_blank" >NU21-09-00297: Souběh výskytu zánětlivých revmatických a psychiatrických onemocnění: epidemiologie, identifikace rizikových skupin a ekonomických nákladů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BMJ Open

ISSN

2044-6055

e-ISSN

2044-6055

Svazek periodika

15

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

"e103686"

Kód UT WoS článku

001637956400001

EID výsledku v databázi Scopus

2-s2.0-105024588019