Self-assessment and rest-activity rhythm monitoring for effective bipolar disorder management: a longitudinal actigraphy study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F25%3A43921696" target="_blank" >RIV/00023752:_____/25:43921696 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21230/25:00388124

Výsledek na webu

<a href="https://link.springer.com/article/10.1186/s40345-025-00401-x" target="_blank" >https://link.springer.com/article/10.1186/s40345-025-00401-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s40345-025-00401-x" target="_blank" >10.1186/s40345-025-00401-x</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Self-assessment and rest-activity rhythm monitoring for effective bipolar disorder management: a longitudinal actigraphy study

Popis výsledku v původním jazyce

Background: Recurrent course and disruption of circadian rhythms are among the core features of bipolar disorder (BD). Thus, ongoing symptom monitoring is an essential part of good clinical management. Objective: We conducted a study to validate the English version of the ASERT (Aktibipo questionnaire), a tool for self-assessment of mood symptoms. We also analyzed the relationship of self-assessed symptoms with clinician ratings and actigraphy measures, and investigated the possibility of predicting depressive episodes using subjective and digital measures. Methods: This was a longitudinal study of twenty individuals with BD, followed for up to 11 months. The participants completed weekly mood self-assessments (ASERT) using a smartphone app and wore wrist actigraphs. During monthly appointments, the severity of their mood symptoms was rated by clinicians, and the participants completed questionnaires addressing overall functioning (FAST), and biological rhythms (BRIAN). Results: The study confirmed the validity and reliability of the ASERT as a measure of subjective mood. Additionally, we found significant associations between ASERT responses, clinical scales, and actigraphy data (ASERT_dep vs. MADRS beta = 1.42, p &lt; 0.001, ASERT_man vs. YMRS beta = 0.38, p &lt; 0.001, mixed-effect model). In our analysis, a combination of self-assessment and actigraphy data detected depression relapse with 67% sensitivity, 90% specificity, 81% balanced accuracy, and AUC of 0.80. Furthermore, we observed a strong correlation between the actigraphy-derived interdaily stability and BRIAN scores (beta=-3.86, p = 0.005) overall functioning, emphasizing the significance of circadian rhythm disruptions in BD. Conclusion: This study highlights the potential of digital tools, such as digitally administered self-assessments and actigraphy, to enhance the management of BD by providing valuable insights into mood states and detecting relapse. Further research is needed to refine and optimize these tools for widespread clinical application, such as informing personalized treatment plans.

Název v anglickém jazyce

Self-assessment and rest-activity rhythm monitoring for effective bipolar disorder management: a longitudinal actigraphy study

Popis výsledku anglicky

Background: Recurrent course and disruption of circadian rhythms are among the core features of bipolar disorder (BD). Thus, ongoing symptom monitoring is an essential part of good clinical management. Objective: We conducted a study to validate the English version of the ASERT (Aktibipo questionnaire), a tool for self-assessment of mood symptoms. We also analyzed the relationship of self-assessed symptoms with clinician ratings and actigraphy measures, and investigated the possibility of predicting depressive episodes using subjective and digital measures. Methods: This was a longitudinal study of twenty individuals with BD, followed for up to 11 months. The participants completed weekly mood self-assessments (ASERT) using a smartphone app and wore wrist actigraphs. During monthly appointments, the severity of their mood symptoms was rated by clinicians, and the participants completed questionnaires addressing overall functioning (FAST), and biological rhythms (BRIAN). Results: The study confirmed the validity and reliability of the ASERT as a measure of subjective mood. Additionally, we found significant associations between ASERT responses, clinical scales, and actigraphy data (ASERT_dep vs. MADRS beta = 1.42, p &lt; 0.001, ASERT_man vs. YMRS beta = 0.38, p &lt; 0.001, mixed-effect model). In our analysis, a combination of self-assessment and actigraphy data detected depression relapse with 67% sensitivity, 90% specificity, 81% balanced accuracy, and AUC of 0.80. Furthermore, we observed a strong correlation between the actigraphy-derived interdaily stability and BRIAN scores (beta=-3.86, p = 0.005) overall functioning, emphasizing the significance of circadian rhythm disruptions in BD. Conclusion: This study highlights the potential of digital tools, such as digitally administered self-assessments and actigraphy, to enhance the management of BD by providing valuable insights into mood states and detecting relapse. Further research is needed to refine and optimize these tools for widespread clinical application, such as informing personalized treatment plans.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30215 - Psychiatry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Bipolar Disorders

ISSN

2194-7511

e-ISSN

2194-7511

Svazek periodika

13

Číslo periodika v rámci svazku

"Article Number 34"

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

1-10

Kód UT WoS článku

001627728100001

EID výsledku v databázi Scopus

2-s2.0-105023427773