Intracellular calcium level in blood platelets during normal and pathological aging and the effect of aluminofluoride complexes.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F99%3A00000018" target="_blank" >RIV/00023752:_____/99:00000018 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Intracellular calcium level in blood platelets during normal and pathological aging and the effect of aluminofluoride complexes.

Popis výsledku v původním jazyce

The platelet free intracellular calcium level ([Ca2+]i) was measured in patients suffering from Alzheimer`s disease (AD), age-matched and young control groups in this study. Also the influence of AlF4- on the [Ca2+]i in all these groups was tested between young and old control healthy subjects. The [Ca2+]i was significantly lower in AD patients than in age-matched and young controls. AlF4- reduces [Ca2+]i in young control group to 85.8+-2.9%, in age-matched control group to 90.2+-2.7% and in AD patientsto 98.5+-3.4% of unstimulated value. There was significant difference between the young controls and AD patients. From these results we can conclude, that the [Ca2+]i is lower in AD patients as compared to age-matched and young healthy controls. AlF4- did not affect the [Ca2+]i in platelets of AD patients.

Název v anglickém jazyce

Intracellular calcium level in blood platelets during normal and pathological aging and the effect of aluminofluoride complexes.

Popis výsledku anglicky

The platelet free intracellular calcium level ([Ca2+]i) was measured in patients suffering from Alzheimer`s disease (AD), age-matched and young control groups in this study. Also the influence of AlF4- on the [Ca2+]i in all these groups was tested between young and old control healthy subjects. The [Ca2+]i was significantly lower in AD patients than in age-matched and young controls. AlF4- reduces [Ca2+]i in young control group to 85.8+-2.9%, in age-matched control group to 90.2+-2.7% and in AD patientsto 98.5+-3.4% of unstimulated value. There was significant difference between the young controls and AD patients. From these results we can conclude, that the [Ca2+]i is lower in AD patients as compared to age-matched and young healthy controls. AlF4- did not affect the [Ca2+]i in platelets of AD patients.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NG15" target="_blank" >NG15: Bioindikátory Alzheimerovy nemoci.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

1999

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Neuropsychopharmacology

ISSN

0924-977X

e-ISSN

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Svazek periodika

9

Číslo periodika v rámci svazku

suppl. 5

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

1

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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