Steroid Conjugates and Their Physiological Role

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023761%3A_____%2F23%3AN0000017" target="_blank" >RIV/00023761:_____/23:N0000017 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.33549/physiolres.935080" target="_blank" >https://doi.org/10.33549/physiolres.935080</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33549/physiolres.935080" target="_blank" >10.33549/physiolres.935080</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Steroid Conjugates and Their Physiological Role

Popis výsledku v původním jazyce

While there are hundreds of synthetic steroids conjugates with acids, sugars, proteins and other molecules, only two types of conjugates occur in living organisms, namely sulfates and glucuronides. Steroid glucuronidation in the human liver is the main mechanism controlling the levels and biological activity of unconjugated hormones, and glucuronides are their main excretion products. This process is generally irreversible. On the other hand, sulfates possess their own biological activity that differs from that of the unconjugated steroid, emphasizing the importance of steroid sulfatases and sulfotransferases. Due to their negative charge, steroid sulfates cannot cross the blood-cell barrier and have to use transporters. Their efflux is mediated by specific transporters of the ATP binding cassette protein group, which thus are further factors controlling their physiological as allosteric modulators of some neurotransmitter receptors, functioning as ion channels, such as gamma-aminobutyric acid, type A (GABAA) receptors or N-methyl-D-aspartate (NMDA) coupled receptors (GPCR), which we believe show the way of genomic effect.

Název v anglickém jazyce

Steroid Conjugates and Their Physiological Role

Popis výsledku anglicky

While there are hundreds of synthetic steroids conjugates with acids, sugars, proteins and other molecules, only two types of conjugates occur in living organisms, namely sulfates and glucuronides. Steroid glucuronidation in the human liver is the main mechanism controlling the levels and biological activity of unconjugated hormones, and glucuronides are their main excretion products. This process is generally irreversible. On the other hand, sulfates possess their own biological activity that differs from that of the unconjugated steroid, emphasizing the importance of steroid sulfatases and sulfotransferases. Due to their negative charge, steroid sulfates cannot cross the blood-cell barrier and have to use transporters. Their efflux is mediated by specific transporters of the ATP binding cassette protein group, which thus are further factors controlling their physiological as allosteric modulators of some neurotransmitter receptors, functioning as ion channels, such as gamma-aminobutyric acid, type A (GABAA) receptors or N-methyl-D-aspartate (NMDA) coupled receptors (GPCR), which we believe show the way of genomic effect.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

<a href="/cs/project/NU21J-01-00040" target="_blank" >NU21J-01-00040: Intraprostatické steroidy: úloha alternativních biosyntetických drah a endokrinních disruptorů v patogenezi karcinomu prostaty</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

0862-8408

Svazek periodika

72

Číslo periodika v rámci svazku

Suppl. 4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

S317-S322

Kód UT WoS článku

001127421100005

EID výsledku v databázi Scopus

2-s2.0-85180384263