Maternal negative affect in pregnancy predicts cytokine levels which in turn predict birth outcomes - A prospective longitudinal study in a low-risk population

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023761%3A_____%2F24%3AN0000047" target="_blank" >RIV/00023761:_____/24:N0000047 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/24:10483815 RIV/00216208:11210/24:10483815

Výsledek na webu

<a href="https://doi.org/10.1016/j.jad.2024.08.141" target="_blank" >https://doi.org/10.1016/j.jad.2024.08.141</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jad.2024.08.141" target="_blank" >10.1016/j.jad.2024.08.141</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Maternal negative affect in pregnancy predicts cytokine levels which in turn predict birth outcomes - A prospective longitudinal study in a low-risk population

Popis výsledku v původním jazyce

Background: Stress and negative mood in pregnancy have been linked to less favorable birth outcomes, but the mechanisms underlying this effect remain largely unknown. We examined associations between emotions in pregnancy, pro- and anti-inflammatory cytokines (IFN-gamma, IL-6, IL-8, IL-10, IL-12, IL-17, MCP-1, MIP-1R, TNF-alpha) and birth outcomes (gestational age at birth and birth weight) in a low-risk sample. Methods: At each trimester of pregnancy, participants (N = 74) completed the Positive and Negative Affect Schedule, Perceived Stress Scale, Edinburgh Postnatal Depression Scale, and State-Trait Anxiety Inventory. They provided blood samples in the third trimester. Multivariate regression with a reduction of dimensionality (orthogonal projection to latent structures) was used to assess associations between maternal emotions, cytokine levels, and birth outcomes. Results: We found significant positive associations between negative mood (depressive symptoms in the second and third trimesters and negative affect in the third trimester) and anti-inflammatory cytokine IL-10 levels, and negative associations between maternal distress in the second and third trimesters and pro-/anti-inflammatory cytokine ratios (IFN-gamma/IL-10, TNF-alpha/IL-10 and IL-6/IL-10). Higher levels of pro-inflammatory cytokines IFN-gamma, IL12, IL-17, and TNF-alpha were associated with younger gestational age at birth and lower birth weight. Limitations: We did not control for relevant factors such as social support, health-related behaviors, or cortisol levels. Conclusions: Negative mood in mid- and late pregnancy may shift cytokine balance toward the anti-inflammatory cytokine dominance. Our results provide further evidence for the negative association between pro-inflammatory cytokines in late pregnancy and gestational age at birth/birth weight, which we observed even in a low-risk population.

Název v anglickém jazyce

Maternal negative affect in pregnancy predicts cytokine levels which in turn predict birth outcomes - A prospective longitudinal study in a low-risk population

Popis výsledku anglicky

Background: Stress and negative mood in pregnancy have been linked to less favorable birth outcomes, but the mechanisms underlying this effect remain largely unknown. We examined associations between emotions in pregnancy, pro- and anti-inflammatory cytokines (IFN-gamma, IL-6, IL-8, IL-10, IL-12, IL-17, MCP-1, MIP-1R, TNF-alpha) and birth outcomes (gestational age at birth and birth weight) in a low-risk sample. Methods: At each trimester of pregnancy, participants (N = 74) completed the Positive and Negative Affect Schedule, Perceived Stress Scale, Edinburgh Postnatal Depression Scale, and State-Trait Anxiety Inventory. They provided blood samples in the third trimester. Multivariate regression with a reduction of dimensionality (orthogonal projection to latent structures) was used to assess associations between maternal emotions, cytokine levels, and birth outcomes. Results: We found significant positive associations between negative mood (depressive symptoms in the second and third trimesters and negative affect in the third trimester) and anti-inflammatory cytokine IL-10 levels, and negative associations between maternal distress in the second and third trimesters and pro-/anti-inflammatory cytokine ratios (IFN-gamma/IL-10, TNF-alpha/IL-10 and IL-6/IL-10). Higher levels of pro-inflammatory cytokines IFN-gamma, IL12, IL-17, and TNF-alpha were associated with younger gestational age at birth and lower birth weight. Limitations: We did not control for relevant factors such as social support, health-related behaviors, or cortisol levels. Conclusions: Negative mood in mid- and late pregnancy may shift cytokine balance toward the anti-inflammatory cytokine dominance. Our results provide further evidence for the negative association between pro-inflammatory cytokines in late pregnancy and gestational age at birth/birth weight, which we observed even in a low-risk population.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30215 - Psychiatry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Affective Disorders

ISSN

0165-0327

e-ISSN

1573-2517

Svazek periodika

366

Číslo periodika v rámci svazku

December

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

345-353

Kód UT WoS článku

001312869300001

EID výsledku v databázi Scopus

2-s2.0-85202859838