MR relaxometrie u Huntingtonovy nemoci: Korelace mezi zobrazovacími, genetickými a klinickými parametry

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F07%3A%230000001" target="_blank" >RIV/00023884:_____/07:#0000001 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/07:3389 RIV/00064165:_____/07:3389

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

MR relaxometry in Huntington´sdisease: correlation between imaging, genetic and clinical parameters

Popis výsledku v původním jazyce

Huntington's disease (HD) is an autosomal dominant disease. Changes of iron content in the brain may be involved in its pathogenesis. We investigated the relationship between T2 time, the number of cytosine-adenine-guanine triplets (CAG) and clinical status. 34 HD patients and 34 controls were scanned at 1.5T and underwent clinical and genetic testing. A multiple echo sequence was employed for T2 measurements. A T2 shortening was found in the pallidum of HD patients. A correlation between the number ofCAG and T2 was found for the left pallidum (decrease in T2, P<0.05) and an inverse correlation for the left caudate (increase in T2, P<0.05). The T2/CAG covariations may reflect changes in levels and forms of iron: this suggests that HD patients with a higher genetic load have more ferritin-bound (safe form) iron in the pallidum and/or more low-molecular (toxic) iron in the caudate. An increase in ?toxic? iron in the caudate may enable oxidative stress and thus underlie progression of th

Název v anglickém jazyce

MR relaxometry in Huntington´sdisease: correlation between imaging, genetic and clinical parameters

Popis výsledku anglicky

Huntington's disease (HD) is an autosomal dominant disease. Changes of iron content in the brain may be involved in its pathogenesis. We investigated the relationship between T2 time, the number of cytosine-adenine-guanine triplets (CAG) and clinical status. 34 HD patients and 34 controls were scanned at 1.5T and underwent clinical and genetic testing. A multiple echo sequence was employed for T2 measurements. A T2 shortening was found in the pallidum of HD patients. A correlation between the number ofCAG and T2 was found for the left pallidum (decrease in T2, P<0.05) and an inverse correlation for the left caudate (increase in T2, P<0.05). The T2/CAG covariations may reflect changes in levels and forms of iron: this suggests that HD patients with a higher genetic load have more ferritin-bound (safe form) iron in the pallidum and/or more low-molecular (toxic) iron in the caudate. An increase in ?toxic? iron in the caudate may enable oxidative stress and thus underlie progression of th

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the Neurological Sciences

ISSN

0022-510X

e-ISSN

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Svazek periodika

263

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

20-25

Kód UT WoS článku

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EID výsledku v databázi Scopus

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