Patients with Abdominal Aortic Aneurysm demonstrate higher levels noncholesterol sterol markers of endogenous cholesterol synthesis

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Patients with Abdominal Aortic Aneurysm demonstrate higher levels noncholesterol sterol markers of endogenous cholesterol synthesis

Popis výsledku v původním jazyce

Aims: To establish the levels of selected non-cholesterol sterols in patients with abdominal aortic aneurysm (AAA) and to compare them with levels in non-AAA patients treated for lipid metabolism disorder. To compare the levels of high-sensitivity C-reactive protein (hs-CRP) and Lp-PLA 2 – inflammation markers in the same group of patients. Study Design: A total of 58 AAA patients indicated for elective surgical procedure and 20 non-AAA patients in the control group treated for lipid metabolism disorder were examined. Methodology: Lathosterol (Lat), desmosterol (Des), lanosterol (Lan), campesterol (Cam) and sitosterol (Sit) were analysed with the use of GC/MS in fasting plasma of patients with AAA and outpatients suffering from lipid metabolism disorder. hs-CRP and lipoprotein-associated phospholipase A2 were analysed in both groups. Results: hs-CRP levels were significantly increased in patients with AAA compared to the control group (med. 3.6 mg/L, IQR 1.83 to 6.0 mg/L vs. 2.05 mg/L, IQR 0.99 to 3.0 mg/L, P = .007). Levels of non-cholesterol precursors of cholesterol synthesis – Lan, Des and Lat – were statistically significantly higher in the group of AAA patients compared to non-AAA patients (Lan: med. 0.28 μmol/L, IQR 0.24 to 0.32 μmol/L vs. 0.23 μmol/L, IQR 0.20 to 0.25 μmol/L, P = .004; Des: med. 3.69 μmol/L, IQR 3.12 to 4.66 μmol/L vs. 3.03 μmol/L, IQR 2.68 to 3.33 μmol/L, P = .0005; Lat: 5.95 μmol/L, IQR 5.18 to 6.9 μmol/L vs. 4.72 μmol/L, IQR 4.32 to 5.22 μmol/L, P = .0002) while there were no statistically significant differences in the absorption parameters of Sit or Cam in either group (Sit: med 6.29 μmol/L, IQR 5.02 to 9.37 μmol/L vs. 6.12 μmol/L, IQR 4.99 to 7.01 μmol/L, P = .65; Cam: med 8.6 μmol/L, IQR 7.31 to 10.71 μmol/L vs. 8.46 μmol/L, IQR 7.24 to 10.86 μmol/L, P = .96). Conclusion: The markers of endogenous cholesterol synthesis in AAA patients are higher compared with those in non-AAA patients treated for lipid metabolism disorder. Higher hs-CRP levels in AAA patients show increased inflammatory activity compared with the control group.

Název v anglickém jazyce

Patients with Abdominal Aortic Aneurysm demonstrate higher levels noncholesterol sterol markers of endogenous cholesterol synthesis

Popis výsledku anglicky

Aims: To establish the levels of selected non-cholesterol sterols in patients with abdominal aortic aneurysm (AAA) and to compare them with levels in non-AAA patients treated for lipid metabolism disorder. To compare the levels of high-sensitivity C-reactive protein (hs-CRP) and Lp-PLA 2 – inflammation markers in the same group of patients. Study Design: A total of 58 AAA patients indicated for elective surgical procedure and 20 non-AAA patients in the control group treated for lipid metabolism disorder were examined. Methodology: Lathosterol (Lat), desmosterol (Des), lanosterol (Lan), campesterol (Cam) and sitosterol (Sit) were analysed with the use of GC/MS in fasting plasma of patients with AAA and outpatients suffering from lipid metabolism disorder. hs-CRP and lipoprotein-associated phospholipase A2 were analysed in both groups. Results: hs-CRP levels were significantly increased in patients with AAA compared to the control group (med. 3.6 mg/L, IQR 1.83 to 6.0 mg/L vs. 2.05 mg/L, IQR 0.99 to 3.0 mg/L, P = .007). Levels of non-cholesterol precursors of cholesterol synthesis – Lan, Des and Lat – were statistically significantly higher in the group of AAA patients compared to non-AAA patients (Lan: med. 0.28 μmol/L, IQR 0.24 to 0.32 μmol/L vs. 0.23 μmol/L, IQR 0.20 to 0.25 μmol/L, P = .004; Des: med. 3.69 μmol/L, IQR 3.12 to 4.66 μmol/L vs. 3.03 μmol/L, IQR 2.68 to 3.33 μmol/L, P = .0005; Lat: 5.95 μmol/L, IQR 5.18 to 6.9 μmol/L vs. 4.72 μmol/L, IQR 4.32 to 5.22 μmol/L, P = .0002) while there were no statistically significant differences in the absorption parameters of Sit or Cam in either group (Sit: med 6.29 μmol/L, IQR 5.02 to 9.37 μmol/L vs. 6.12 μmol/L, IQR 4.99 to 7.01 μmol/L, P = .65; Cam: med 8.6 μmol/L, IQR 7.31 to 10.71 μmol/L vs. 8.46 μmol/L, IQR 7.24 to 10.86 μmol/L, P = .96). Conclusion: The markers of endogenous cholesterol synthesis in AAA patients are higher compared with those in non-AAA patients treated for lipid metabolism disorder. Higher hs-CRP levels in AAA patients show increased inflammatory activity compared with the control group.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

30102 - Immunology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Advances in Medicine and Medical Research

ISSN

2456-8899

e-ISSN

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Svazek periodika

22

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

6

Strana od-do

1-6

Kód UT WoS článku

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EID výsledku v databázi Scopus

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