Evaluation of aspirin's effect on platelet function early after coronary artery bypass grafting

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F12%3A00009555" target="_blank" >RIV/00023884:_____/12:00009555 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11320/12:10125930 RIV/00216208:11120/12:43897916 RIV/00064173:_____/12:43897916 RIV/00064190:_____/12:#0000470

Výsledek na webu

<a href="https://pubmed.ncbi.nlm.nih.gov/22281116/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/22281116/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1053/j.jvca.2011.12.004" target="_blank" >10.1053/j.jvca.2011.12.004</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evaluation of aspirin's effect on platelet function early after coronary artery bypass grafting

Popis výsledku v původním jazyce

Objective: Aspirin therapy decreases mortality and ischemic complication rates after coronary artery bypass grafting (CABG). However, platelet inhibition after oral aspirin seems to be insufficient in the early postoperative period. There are incomplete data reporting aspirin efficacy early after CABG. The aim of this study was to assess the pharmacologic effect of aspirin on platelets in the first postoperative days using the most specific laboratory tests for the evaluation of aspirin efficacy. Design: A prospective study. Setting: A clinical study in one cardiac surgery center and measurements in two pharmacologic institutions. Participants: Thirty patients. Interventions: Postoperative aspirin efficacy (200 mg/d) was assessed by the suppression of serum thromboxane B-2 (TXB2) and by arachidonic acid-induced aggregometry using the MULTIPLATE analyzer. Samples were collected before surgery and on postoperative days 1-5. Methods and Main Results: The median baseline value (range) of serum TxB(2) was 1.6 ng/mL (1.4-1.9). The median TxB(2) inhibition >90% (the value required for full platelet inhibition) was not achieved until day 5 (-91%, 0.13 ng/mL [0.08-0.22], p < 0.001) and in only 55% of patients. The median baseline ASPI value was 805 (640-975) aggregation units (AU)*min. A significant decrease in aspirin insufficiency was not seen before postoperative day 5 (390 [243621], p < 0.003) and only 34% of patients reached an effective platelet inhibition on day 5 (cutoff < 300 AU*min). Conclusions: The effect of aspirin on inhibition of TxB(2) production and arachidonic acid-induced platelet aggregation is impaired during the first postoperative days after CABG. A more effective antiplatelet strategy presumably could increase early graft patency and improve clinical outcomes after CABG. (C) 2012 Published by Elsevier Inc.

Název v anglickém jazyce

Evaluation of aspirin's effect on platelet function early after coronary artery bypass grafting

Popis výsledku anglicky

Objective: Aspirin therapy decreases mortality and ischemic complication rates after coronary artery bypass grafting (CABG). However, platelet inhibition after oral aspirin seems to be insufficient in the early postoperative period. There are incomplete data reporting aspirin efficacy early after CABG. The aim of this study was to assess the pharmacologic effect of aspirin on platelets in the first postoperative days using the most specific laboratory tests for the evaluation of aspirin efficacy. Design: A prospective study. Setting: A clinical study in one cardiac surgery center and measurements in two pharmacologic institutions. Participants: Thirty patients. Interventions: Postoperative aspirin efficacy (200 mg/d) was assessed by the suppression of serum thromboxane B-2 (TXB2) and by arachidonic acid-induced aggregometry using the MULTIPLATE analyzer. Samples were collected before surgery and on postoperative days 1-5. Methods and Main Results: The median baseline value (range) of serum TxB(2) was 1.6 ng/mL (1.4-1.9). The median TxB(2) inhibition >90% (the value required for full platelet inhibition) was not achieved until day 5 (-91%, 0.13 ng/mL [0.08-0.22], p < 0.001) and in only 55% of patients. The median baseline ASPI value was 805 (640-975) aggregation units (AU)*min. A significant decrease in aspirin insufficiency was not seen before postoperative day 5 (390 [243621], p < 0.003) and only 34% of patients reached an effective platelet inhibition on day 5 (cutoff < 300 AU*min). Conclusions: The effect of aspirin on inhibition of TxB(2) production and arachidonic acid-induced platelet aggregation is impaired during the first postoperative days after CABG. A more effective antiplatelet strategy presumably could increase early graft patency and improve clinical outcomes after CABG. (C) 2012 Published by Elsevier Inc.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Cardiothoracic and Vascular Anesthesia

ISSN

1053-0770

e-ISSN

—

Svazek periodika

26

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

575-580

Kód UT WoS článku

000306448500007

EID výsledku v databázi Scopus

2-s2.0-84863492797