Combination of Steroids and Azathioprine in the Treatment of Ormond's Disease--A Single Centre Retrospective Analysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F16%3A%230006976" target="_blank" >RIV/00023884:_____/16:#0006976 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Combination of Steroids and Azathioprine in the Treatment of Ormond's Disease--A Single Centre Retrospective Analysis

Popis výsledku v původním jazyce

Background: We present our retrospective analysis of 28 patients treated in our department during 1997 2013 for Ormond disease. Patients and Methods: In our retrospective survey, we analyse diagnostic approaches, the clinical history, surgical and immunosuppressive therapies and their subsequent effect on our patients. Measurement of the C reactive protein, creatinin, ECR, IgG4 were compared in the follow up of the patients. Patients with established disease activity (26 patients) were given immunosuppressive treatment, using corticosteroids in combination with azathioprine. Results: In the cohort as a whole, immunosuppressive therapy was applied in 26 patients, in 2 patients it was not used as no inflammatory activity was found from the disease. In all 26 patients, CT showed that immunosuppressive treatment resulted in partial or complete regression of inflammatory infiltrate. Out of the total number of 26 patients, 2 patient experienced disease exacerbation-after 7 and 16 months after the immunosuppressive treatment was discontinued. The longest follow-up period is 16 years; the shortest one is 21 months. Conclusions: Idiopathic retroperitoneal fibrosis Ormond s disease is a systemic autoimmune disease with serious complications. Standard treatment involves a combination of surgery and immunosuppressive treatment. Combination of corticosteroids and azathioprine represent potencially safe and useful methods of treatment.

Název v anglickém jazyce

Combination of Steroids and Azathioprine in the Treatment of Ormond's Disease--A Single Centre Retrospective Analysis

Popis výsledku anglicky

Background: We present our retrospective analysis of 28 patients treated in our department during 1997 2013 for Ormond disease. Patients and Methods: In our retrospective survey, we analyse diagnostic approaches, the clinical history, surgical and immunosuppressive therapies and their subsequent effect on our patients. Measurement of the C reactive protein, creatinin, ECR, IgG4 were compared in the follow up of the patients. Patients with established disease activity (26 patients) were given immunosuppressive treatment, using corticosteroids in combination with azathioprine. Results: In the cohort as a whole, immunosuppressive therapy was applied in 26 patients, in 2 patients it was not used as no inflammatory activity was found from the disease. In all 26 patients, CT showed that immunosuppressive treatment resulted in partial or complete regression of inflammatory infiltrate. Out of the total number of 26 patients, 2 patient experienced disease exacerbation-after 7 and 16 months after the immunosuppressive treatment was discontinued. The longest follow-up period is 16 years; the shortest one is 21 months. Conclusions: Idiopathic retroperitoneal fibrosis Ormond s disease is a systemic autoimmune disease with serious complications. Standard treatment involves a combination of surgery and immunosuppressive treatment. Combination of corticosteroids and azathioprine represent potencially safe and useful methods of treatment.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

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Projekt

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Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Prague Medical Report

ISSN

1214-6994

e-ISSN

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Svazek periodika

117

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

34-41

Kód UT WoS článku

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EID výsledku v databázi Scopus

2-s2.0-84974654795