Gamma knife radiosurgery for local recurrence of glioblastoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F18%3A00007840" target="_blank" >RIV/00023884:_____/18:00007840 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Gamma knife radiosurgery for local recurrence of glioblastoma

Popis výsledku v původním jazyce

OBJECT. Local recurrence of glioblastoma is observed in most patients after standard oncologic treatment (surgery, chemotherapy and radiotherapy). Gamma Knife radiosurgery has been used to treat these recurrence tumors in selected cases and retrospective analysis of treatment was performed. METHODS. Altogether 126 patients were treated for glioblastoma during 1992-2014 in our center. There were 69 (55%) male and 57 (45%) female with median age of 56 years (range 17-80 years). From this group 123 (98%) underwent surgery, 126 (100%) radiotherapy and 116 (92%) chemotherapy before the LGK radiosurgery. Median Karnofsky score before the LGK radiosurgery for patients in this group was 90% (range 50-100), median time from diagnosis of glioblastoma to the LGK radiosurgery was 12 months (range 1- 96 months). Median tumor volume was 3.75 cm3 (range 0.04 – 37.10 cm3). Patients in this study were treated by the LGK radiosurgery performed in single fraction with median minimal tumor dose of 12 Gy (range 10 – 25 Gy) on median 50 % (range 40 – 86 %) isodose line. Two and more LGK radiosurgeries were performed in 19 (15 %) cases. Repeated radiosurgery was performed in 19 (15 %) cases median time 9.6 months (range 2-45 months) from the initial gamma knife surgery. Median prescribed dose in these patients was 12.6 Gy (range 10-15 Gy), median volume 5.8 cm3 (range 0.1-13.7 cm3). RESULTS. Median patients’ survival since glioblastoma diagnosis was 20 months (range 6 – 237 months). Median patients’ survival after the LGK radiosurgery was 7 months (range 1 – 223 months). 1 year survival after the LGK radiosurgery was 27% of patients, 2 years – 8% of patients and more than 3 years – 4% of patients. Tumor regression on MR images was observed in 17% of patients, the median time was 7 months. The median time to tumor progression on MR images after Gamma Knife treatment was 8,5 months. No treatment related radionecrosis with expansive behavior was detected after radiosurgery. CONCLUSION. Presented study showed that Gamma Knife radiosurgery is a safe palliative treatment modality in selected patients with recurrent glioblastoma.

Název v anglickém jazyce

Gamma knife radiosurgery for local recurrence of glioblastoma

Popis výsledku anglicky

OBJECT. Local recurrence of glioblastoma is observed in most patients after standard oncologic treatment (surgery, chemotherapy and radiotherapy). Gamma Knife radiosurgery has been used to treat these recurrence tumors in selected cases and retrospective analysis of treatment was performed. METHODS. Altogether 126 patients were treated for glioblastoma during 1992-2014 in our center. There were 69 (55%) male and 57 (45%) female with median age of 56 years (range 17-80 years). From this group 123 (98%) underwent surgery, 126 (100%) radiotherapy and 116 (92%) chemotherapy before the LGK radiosurgery. Median Karnofsky score before the LGK radiosurgery for patients in this group was 90% (range 50-100), median time from diagnosis of glioblastoma to the LGK radiosurgery was 12 months (range 1- 96 months). Median tumor volume was 3.75 cm3 (range 0.04 – 37.10 cm3). Patients in this study were treated by the LGK radiosurgery performed in single fraction with median minimal tumor dose of 12 Gy (range 10 – 25 Gy) on median 50 % (range 40 – 86 %) isodose line. Two and more LGK radiosurgeries were performed in 19 (15 %) cases. Repeated radiosurgery was performed in 19 (15 %) cases median time 9.6 months (range 2-45 months) from the initial gamma knife surgery. Median prescribed dose in these patients was 12.6 Gy (range 10-15 Gy), median volume 5.8 cm3 (range 0.1-13.7 cm3). RESULTS. Median patients’ survival since glioblastoma diagnosis was 20 months (range 6 – 237 months). Median patients’ survival after the LGK radiosurgery was 7 months (range 1 – 223 months). 1 year survival after the LGK radiosurgery was 27% of patients, 2 years – 8% of patients and more than 3 years – 4% of patients. Tumor regression on MR images was observed in 17% of patients, the median time was 7 months. The median time to tumor progression on MR images after Gamma Knife treatment was 8,5 months. No treatment related radionecrosis with expansive behavior was detected after radiosurgery. CONCLUSION. Presented study showed that Gamma Knife radiosurgery is a safe palliative treatment modality in selected patients with recurrent glioblastoma.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

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Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Svazek periodika

39

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

SE - Švédské království

Počet stran výsledku

7

Strana od-do

281-287

Kód UT WoS článku

000453287500002

EID výsledku v databázi Scopus

2-s2.0-85060123594