Susceptibility and diffusion MRI biomarkers predict development of Parkinsonism in iRBD

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F25%3A00010172" target="_blank" >RIV/00023884:_____/25:00010172 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/25:10505506 RIV/00216208:11120/25:43929080 RIV/00064165:_____/25:10505506

Výsledek na webu

<a href="https://www-nature-com.ezproxy.lib.cas.cz/articles/s41531-025-01174-x" target="_blank" >https://www-nature-com.ezproxy.lib.cas.cz/articles/s41531-025-01174-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41531-025-01174-x" target="_blank" >10.1038/s41531-025-01174-x</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Susceptibility and diffusion MRI biomarkers predict development of Parkinsonism in iRBD

Popis výsledku v původním jazyce

Quantitative MRI techniques, including quantitative susceptibility mapping (QSM) and diffusion tensor imaging (DTI), may detect early neurodegenerative changes in alpha-synucleinopathies, especially within the midbrain. This study evaluated their potential to predict phenoconversion to overt synucleinopathy in 79 patients with isolated REM sleep behavior disorder (iRBD) followed annually over 5.6 +/- 3.0 years. Phenoconversion, defined by emergence of parkinsonism or dementia, occurred in 21 patients. Baseline QSM and DTI data were analyzed to identify regional brain differences, revealing increased magnetic susceptibility and fractional anisotropy (FA) in the bilateral cerebral peduncle of phenoconverters. Increased magnetic susceptibility and FA within this region were associated with higher phenoconversion risk (FA: hazard ratio (HR) = 1.84, susceptibility: HR = 1.67). Their combined score predicted phenoconversion with accuracy similar to dopamine-transporter imaging (HR 2.58 vs 2.85). Findings suggest that increased susceptibility and FA in the cerebral peduncle may serve as biomarkers of early phenoconversion, potentially reflecting compensatory neuroplastic changes in subthalamo-pallidal pathways.

Název v anglickém jazyce

Susceptibility and diffusion MRI biomarkers predict development of Parkinsonism in iRBD

Popis výsledku anglicky

Quantitative MRI techniques, including quantitative susceptibility mapping (QSM) and diffusion tensor imaging (DTI), may detect early neurodegenerative changes in alpha-synucleinopathies, especially within the midbrain. This study evaluated their potential to predict phenoconversion to overt synucleinopathy in 79 patients with isolated REM sleep behavior disorder (iRBD) followed annually over 5.6 +/- 3.0 years. Phenoconversion, defined by emergence of parkinsonism or dementia, occurred in 21 patients. Baseline QSM and DTI data were analyzed to identify regional brain differences, revealing increased magnetic susceptibility and fractional anisotropy (FA) in the bilateral cerebral peduncle of phenoconverters. Increased magnetic susceptibility and FA within this region were associated with higher phenoconversion risk (FA: hazard ratio (HR) = 1.84, susceptibility: HR = 1.67). Their combined score predicted phenoconversion with accuracy similar to dopamine-transporter imaging (HR 2.58 vs 2.85). Findings suggest that increased susceptibility and FA in the cerebral peduncle may serve as biomarkers of early phenoconversion, potentially reflecting compensatory neuroplastic changes in subthalamo-pallidal pathways.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

npj Parkinsons Disease

ISSN

2373-8057

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

—

Kód UT WoS článku

001620845500004

EID výsledku v databázi Scopus

2-s2.0-105022636077